98502-96-6Relevant articles and documents
Synthetic process for acipimox
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Paragraph 0055; 0056, (2017/01/17)
The invention provides a synthetic process for acipimox. The synthetic process comprises steps: firstly, 5-methylpyrazine-2-carboxylic acid and hydrogen peroxide are reacted under action of catalysts in an aqueous solution; secondly, an auxiliary agent is added into the solution obtained in the first step, and the auxiliary agent is one selected from sulfite, bisulfate, oxalic acid and oxalate; thirdly, active carbon is added in the solution obtained in the second step and filtering is carried out; fourthly, the solution obtained in the third step is subjected to cooling crystallization and drying, and an acipimox finshed product is obtained. The synthetic process can lower the crystallization frequency effectively, avoids recrystallization operation, raises the yield and lowers the production cost.