98303-20-9 Usage
Description
N-Boc-2-piperidinecarboxylic acid, also known as DL-Boc-pipecolic acid, is a protected form of pipecolic acid, which is an intermediate metabolite of L-Lysine. It plays a significant role in the diagnosis of peroxisomal disorders in infants, such as Zeilweiger syndrome, due to its accumulation in the body.
Uses
Used in Pharmaceutical Industry:
N-Boc-2-piperidinecarboxylic acid is used as a catalyst in asymmetric Mannich reactions for the synthesis of various pharmaceutical compounds. Its ability to selectively form desired products in these reactions makes it a valuable tool in the development of new drugs.
Used in Diagnostic Applications:
N-Boc-2-piperidinecarboxylic acid is used as a biomarker for the diagnosis of peroxisomal disorders in infants, such as Zeilweiger syndrome. Its accumulation in the body serves as an indicator of these rare genetic disorders, aiding in early detection and treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 98303-20-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,3,0 and 3 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 98303-20:
(7*9)+(6*8)+(5*3)+(4*0)+(3*3)+(2*2)+(1*0)=139
139 % 10 = 9
So 98303-20-9 is a valid CAS Registry Number.
InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(15)12-7-5-4-6-8(12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/p-1/t8-/m0/s1
98303-20-9Relevant articles and documents
Discovery of 23 Natural Tubulysins from Angiococcus disciformis An d48 and Cystobacter SBCb004
Chai, Yi,Pistorius, Dominik,Ullrich, Angelika,Weissman, Kira J.,Kazmaier, Uli,Mueller, Rolf
experimental part, p. 296 - 309 (2010/06/19)
The tubulysins are a family of complex peptides with promising cytotoxic activity against multi-drug-resistant tumors. To date, ten tubulysins have been described from the myxobacterial strains Angiococcus disciformis An d48 and Archangium gephyra Ar 315. We report here a third producing strain, Cystobacter sp. SBCb004. Comparison of the tubulysin biosynthetic gene clusters in SBCb004 and An d48 reveals a conserved architecture, allowing the assignment of cluster boundaries. A SBCb004 strain containing a mutant in the putative cyclodeaminase gene tubZ accumulates pretubulysin A, the proposed first enzyme-free intermediate in the pathway, whose structure we confirm by NMR. We further show, using a combination of feeding studies and structure elucidation by NMR and high-resolution tandem mass spectrometry, that SBCb004 and An d48 together biosynthesize 22 additional tubulysin derivatives. These data reveal the inherently diversity-oriented nature of the tubulysin biosynthetic pathway.