98-28-2

Basic information

• Product Name: 4-TERT-BUTYL-2-CHLOROPHENOL
• Synonyms: 4-TERT-BUTYL-2-CHLOROPHENOL;2-CHLORO-4-TERT-BUTYLPHENOL;phenol, 2-chloro, 4-t-butyl;Phenol, 4-tert-butyl-2-chloro-;4-TERT-BUTYL-2-CHLOROPHENOL, 10MG, NEAT;NSC 8464;4-TERT-BUTYL-2-CHLOROPHENOL: TECH., 90%
• CAS NO: 98-28-2
• Molecular Formula: C₁₀H₁₃ClO
• Molecular Weight: 184.66
• EINECS: 202-652-3
• Product Categories: A-BAlphabetic;Alpha sort;B;BI - BZEnvironmental Standards;Metabolites;Pesticides&Metabolites
• Mol File: 98-28-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 238.7°Cat760mmHg
• Flash Point: 98.2°C
• Appearance: /
• Density: 1.109g/cm³
• Vapor Pressure: 0.0271mmHg at 25°C
• Refractive Index: 1.529
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
• PKA: 8.71±0.18(Predicted)
• CAS DataBase Reference: 4-TERT-BUTYL-2-CHLOROPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-TERT-BUTYL-2-CHLOROPHENOL(98-28-2)
• EPA Substance Registry System: 4-TERT-BUTYL-2-CHLOROPHENOL(98-28-2)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-41-37/38-22
• Safety Statements: 36/37-45-39-26
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 98-28-2(Hazardous Substances Data)

Usage

Uses

4-tert-Butyl-2-chlorophenol is a colorless liquid that used in organic synthesis.

InChI:InChI=1/C10H13ClO/c1-10(2,3)7-4-5-9(12)8(11)6-7/h4-6,12H,1-3H3

Upstream product

• 107-39-1 2,4,4-trimethyl-1-pentene 
• 95-57-8 2-monochlorophenol 
• 598-49-2 N-chloroacetamide 
• 98-54-4 para-tert-butylphenol 
• 115-11-7 isobutene 
• 75-65-0 tert-butyl alcohol 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 76-05-1 trifluoroacetic acid 
• 96-76-4 2,4-di-tert-Butylphenol 

Downstream Products

• 102475-98-9 4-tert-butyl-2-chloro-6-piperidinomethyl-phenol 
• 102596-48-5 4-tert-butyl-2-chloro-6-morpholinomethyl-phenol 
• 7598-31-4 toluene-4-sulfonic acid-(4-tert-butyl-2-chloro-phenyl ester) 
• 916-24-5 4-tert.-Butyl-2,6-bis-(3-chlor-2-hydroxy-5-tert.-butyl-benzyl)-phenol 
• 802-62-0 4,4'-di-tert-butyl-6,6'-dichloro-2,2'-methanediyl-di-phenol 
• 63350-04-9 Methyl α-(2-chloro-4-tert-butylphenoxy)-α-[p-(p-chlorophenoxy)phenyl]acetate 
• 1392198-00-3 4-tert-Butyl-2-chloro-6-{[(2-(dimethylamino)ethyl)(2-methoxybenzyl)amino]methyl}phenol 
• 106381-19-5 4-tert-butyl-2-chloro-6-(3,3-dichloro-2-methyl-allyl)-phenol 
• 101876-79-3 4-tert-butyl-6,4',6'-trichloro-2,2'-methanediyl-di-phenol 
• 101353-18-8 furan-2-carboxylic acid-(4-tert-butyl-2-chloro-phenyl ester) 
• 103757-75-1 1,4-bis-(5-tert-butyl-3-chloro-2-hydroxy-benzyl)-piperazine 
• 873055-61-9 4-tert-butyl-2-chloro-5-aminophenol 
• 873055-60-8 4-tert-butyl-2-chloro-5-nitrophenol 
• 873055-59-5 4-tert-butyl-2-chloro-5-nitrophenyl methyl carbonate 

Relevant articles and documents

Synthesis of Ti-Al binary oxides and their catalytic application for C-H halogenation of phenols, aldehydes and ketones

Traditional C–H halogenation of organic compounds often requires corrosive agent or harsh condition, and current researches are focused on the use of noble metals as catalyst. In order to give an efficient, benign, activity-adjustable and cost-effective system for halogenation, a series of Ti-Al mixed oxides are prepared as catalyst through sol-gel in this work. Characterizations reveal all catalysts contain more aluminum than titanium, but preparative conditions affect their composition and crystallinity. Monitoring of particle size, zeta potential and UV–vis of preparative solution reveals that formation of catalyst colloids undergoes chemical reaction, affecting catalyst morphology. In halogenation, all catalysts show moderate to high activities, copper chloride proves to be an effective halogen source rather than sodium chloride. The chlorination and bromination are better than iodization, phenol and ketone appear to be more appropriate substrates than aldehyde. Additionally, oxide backbone of catalyst is more durable than its organic components during recycling. This study may provide new catalytic materials for progress of C–H activation.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.