Xi:Irritant;97-64-3Relevant articles and documents
Ni-Catalyzed C(sp3)–O Arylation of α-Hydroxy Esters
Monteith, John J.,Rousseaux, Sophie A. L.
supporting information, p. 9485 - 9489 (2021/12/09)
A Negishi cross-coupling of α-hydroxy ester derivatives and arylzinc reagents has been developed. This reaction tolerates both primary and secondary C(sp3)–O alcohol precursors and achieves efficient cross-coupling under Ni catalysis without the need for added external metal reductant, photocatalyst, or additives. The arylation of readily accessible C(sp3)–O electrophiles in this operationally simple, rapid, and mild reaction provides a complementary way of accessing desirable α-aryl ester products.
Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination
Yao, Peiyuan,Marshall, James R.,Xu, Zefei,Lim, Jesmine,Charnock, Simon J.,Zhu, Dunming,Turner, Nicholas J.
supporting information, p. 8717 - 8721 (2021/03/16)
N-Substituted α-amino esters are widely used as chiral intermediates in a range of pharmaceuticals. Here we report the enantioselective biocatalyic synthesis of N-substituted α-amino esters through the direct reductive coupling of α-ketoesters and amines employing sequence diverse metagenomic imine reductases (IREDs). Both enantiomers of N-substituted α-amino esters were obtained with high conversion and excellent enantioselectivity under mild reaction conditions. In addition >20 different preparative scale transformations were performed highlighting the scalability of this system.
Process method for producing ethyl lactate by using reactive distillation dividing wall tower technology
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Paragraph 0039; 0040; 0046-0049, (2020/02/14)
The invention provides a process method for producing ethyl lactate by using a reactive distillation dividing wall tower technology. According to the process, the production of ethyl lactate is completed in a reactive distillation dividing wall tower, an esterification reaction of lactic acid and ethanol is completed in a middle section feeding side reaction section of the reactive distillation dividing wall tower to generate ethyl lactate and water, and the separation of ethanol and esterification product water is completed through a middle section extraction side rectification section, meanwhile, ethyl lactate purification is realized in a middle section feeding side stripping section and a middle section extracting side stripping section, and finally a food-grade ethyl lactate product is obtained at the bottom of the tower. Compared with the prior art, the process has the advantages of high ethyl lactate product yield, high equipment integration, short process flow, low one-time investment, low operation cost and the like.
