97-18-7 Usage
Description
Bithionol is an antihelmintic drug with bacteriostatic and fungicidal properties. It is also an inhibitor of glutamate dehydrogenase (IC50 = 4.8 μM bovine GDH1).
Uses
Used in Pharmaceutical Industry:
Bithionol is used as an antihelmintic drug for treating parasitic worm infections.
Used in Antimicrobial Applications:
Bithionol is used as a bactericide and fungicide for its bacteriostatic and fungicidal properties.
Used in Agriculture:
Bithionol is used as a proposed agricultural fungicide to protect crops from fungal infections.
Used in Food Industry:
Bithionol is used as a food additive in feed and drinking water for food-producing animals, and it is permitted in food for human consumption.
Used in Personal Care:
Bithionol is used as a deodorant and in germicide pharmaceuticals, antibacterial agent in soaps, cosmetics, and veterinary antiseptic and antihelminthic products.
Used in Industrial Cleaners:
Bithionol is used as an ingredient in industrial cleansers for its antimicrobial properties.
Pharmacology and mechanism of action
Bithionol is a dichlorophenol which is structurally related to hexachlorophene and niclosamide. It was introduced into clinical medicine three decades ago. The drug has been replaced by praziquantel, but it is still used in some areas of the world, particularly against Fasciola hepatica.
The mechanism of action of bithionol is not well known. It inhibits oxidative phosphorylation of Paragonimus westermani and causes morphological alterations in Fasciola hepatica[1,2,3].
Indications
Infections with Parogonimus westermani (lung fluke) and Fasciola hepatica (liver fluke).
Bithionol should only be used as a second-line drug in the treatment of paragonimiasis for those patients who fail to respond to full course therapy with praziquantel. Triclabendazole, which is a new drug still under clinical evaluation, will most probably become the drug of choice against fascioliasis in the near future.
Indications
Bithionol (Actamer) is a phenolic derivative whose
mode of action is related to uncoupling of parasitespecific
fumarate reductase–mediated oxidative phosphorylation.
The drug is administered orally and is absorbed
from the intestinal tract. Peak blood levels are achieved in
4 to 8 hours. Excretion is mainly by the kidneys.
Bithionol is used in treatment of F. hepatica infections
and as an alternative to praziquantel in the treatment
of infestation by P. westermani. It is highly active
against the adult worm but exerts no action against the
migratory stages. A second course of treatment is required
for complete cure in 20 to 30% of patients.
Side effects are generally mild and transient; they
include nausea, vomiting, diarrhea, headache, dizziness,
urticaria, and other skin rashes in 50% of patients.
Side effects
Side effects are common, but minor. About one third of the patients may experience diarrhoea that may be accompanied by anorexia, nausea and vomiting. Skin rashes or urticaria usually together with itching may be seen. Phototoxic reactions can occur[1,4,5,6].
Contraindications and precautions
Efficacy and safety of the drug has not been established in children under 8 years of age.
Preparations
? Bitin? (Tanabe Seiyaky) Tablets 500 mg.
References
1. Barret-Connor E (1982). Drugs for the treatment of parasitic infection. Med Clin North Am, 66, 245–255.
2. Dawes B. Some apparent effects of Bithionol (Actamer) on Fasciola hepatica. Nature. 209, 424– 425.
3. Yokogawa M, Muneo I (1965). Paragonimiasis. Adv Parasitol, 3, 99–158.
4. Chung HL, Ho LY, Hsu CP, Ts’ao WJ (1981). Recent progress in studies of Paragonimus and paragonimiasis control in China. Chin Med J, 94, 493–494.
5. Kim JS (1970). Treatment of Paragonimus westermani: infections with Bithionol. Am J Trop Med Hyg, 19, 940–942.
6. O’Quinn SE, Kennedy CB, Isbell KH (1967). Contact photodermatitis due to bithionol and related compounds. J Am Med Ass, 199, 89–92.
References
1) Li?et al. (2009),?Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics; J. Biol. Chem.,?284?22988
2) Zocher?et al. (2012),?Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2; Mol. Biochem. Parasitol.,?183?52
World Health Organization (WHO)
Bithionol, which has bactericidal and anthelminthic activity, was
formerly available in soaps. By the late 1960s use of such preparations had been
associated with a risk of photosensitivity reactions and cross-sensitivity with other
halogenated disinfectants. This resulted in their withdrawal in the USA. Oral
preparations of bithionol remain available for the treatment of paragonimiasis and
fascioliasis.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Bithionol is incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials may generate heat and toxic or flammable gases.
Hazard
Toxic by ingestion.
Health Hazard
ACUTE/CHRONIC HAZARDS: Bithionol is a skin irritant. When heated to decomposition or upon contact with acid or acid fumes, toxic fumes are evolved.
Fire Hazard
Flash point data is not available for Bithionol, but Bithionol is probably combustible.
Mechanism of action
Biothionol is bis-dichlorophenol, and it is structurally similar to hexachlorophene. It is the
antihelmintic drug of choice for treating humans infected with Fasciola hepatica. It is an
alternative drug to praziquantel that is used for treating pulmonary and cerebral paragonimiasis. The exact mechanism of action is not known, although it seems likely that it
inhibits oxidative phosphorylation in Paeagonumus westermani. Synonyms of this drug
are actamer, bitin, prevenol, and others.
Clinical Use
2,2’-Thiobis(4,6-dichlorophenol), or bis(2-hydroxy-3,5-dichlorophenyl)sulfide (Lorothidol, Bithin), a chlorinatedbisphenol, was formerly used in soaps and cosmetics for itsantimicrobial properties but was removed from the marketfor topical use because of reports of contact photodermatitis.Bithionol has useful anthelmintic properties and hasbeen used as a fasciolicide and taeniacide. It is still consideredthe agent of choice for the treatment of infestationscaused by the liver fluke Fasciola hepatica and the lungfluke Paragonimus westermani. Niclosamide is believed tobe superior to it for the treatment of tapeworm infestations.
Synthesis
Bithionol, 2,2-thiobis(4,6-dichlorophenol) (38.1.38), is made by reacting a
solution of 2,4-dichlorophenol in carbon tetrachloride with sulfur chloride in the presence
of aluminum chloride.
Potential Exposure
It is used as a surfactant-formulated
antimicrobial against bacteria, molds and yeast. It is proposed
as an agricultural fungicide. Other uses include deodorant,
germicide, fungistat, and in the manufacture of pharmaceuticals.
It is no longer allowed to be used in cosmetics. A food
additive in feed and drinking water of animals. Also a food
additive permitted in food for human consumption.
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides.
Check Digit Verification of cas no
The CAS Registry Mumber 97-18-7 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 7 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 97-18:
(4*9)+(3*7)+(2*1)+(1*8)=67
67 % 10 = 7
So 97-18-7 is a valid CAS Registry Number.
97-18-7Relevant articles and documents
ANTIBIOTIC COMPOUNDS
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, (2020/12/30)
The present application provides compounds and methods for treating bacterial infections, including bacterial infections caused by MRSA.
Compositions
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, (2008/06/13)
The problem of providing a storage stable anti-calculus toothpaste comprising a tripolyphosphate salt is remedied by incorporating more than 4% of the salt and having the pH from about 8 to about 10. A tripolyphosphate salt may also be combined with a noncationic anti-bacterial agent such as triclosan to provide a composition having anti-calculus and anti-plaque activity.
Dentifrice compositions
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, (2008/06/13)
It is disclosed that a dentifrice which includes a surfactant and an anti-plaque agent comprising a substantially water-insoluble non-cationic antimicrobial agent or a zinc salt or a mixture thereof has enhanced activity when the dentifrice comprises at least 0.2% by weight of a lamellar liquid crystal surfactant phase having a lamellar spacing of less than 6.0 nm.
