96917-26-9

Basic information

• Product Name: Artanin
• Synonyms: Artanin;5,7-Dimethoxy-8-[(3-methyl-2-butenyl)oxy]-2H-1-benzopyran-2-one
• CAS NO: 96917-26-9
• Molecular Formula: C16H18O5
• Molecular Weight: 290.31112
• Mol File: 96917-26-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 104-107 °C(Solv: ethyl ether (60-29-7); hexane (110-54-3))
• Boiling Point: 460.5±45.0 °C(Predicted)
• Appearance: /
• Density: 1.168±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Artanin(CAS DataBase Reference)
• NIST Chemistry Reference: Artanin(96917-26-9)
• EPA Substance Registry System: Artanin(96917-26-9)

Safety Data

• Hazardous Substances Data: 96917-26-9(Hazardous Substances Data)

Usage

General Description

Artanin is a chemical compound that is a potent natural insecticide derived from the neem tree (Azadirachta indica). It contains a mixture of limonoids, which are bitter-tasting and toxic to insects, and has been found to have significant pesticidal activity against a wide range of agricultural pests. Artanin works by disrupting the insects' hormone systems and has been shown to be effective in controlling pests such as thrips, mites, aphids, and whiteflies. It is considered to be a safer alternative to synthetic chemical insecticides, as it has minimal impact on non-target organisms and does not leave harmful residues in the environment. Artanin has potential applications in organic farming and sustainable pest management practices.

Upstream product

• 61899-44-3 8-hydroxy-5,7-dimethoxycoumarin (leptodactylone) 
• 870-63-3 prenyl bromide 
• 16416-41-4 1-Bromo-3-methyl-butene 

Relevant articles and documents

Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells

The presumption that some coumarins might be lead compounds in the search for new differentiation agents against leukemia is based on the fact that natural coumarins, 5-(3-methyl-2-butenyloxy)-6,7-methylenedioxycoumarin (C-2) and 5-methoxy-6,7-methylenedioxycoumarin (C-1) inhibit proliferation and induce differentiation in U-937 cells [Riveiro, M. E.; Shayo, C.; Monczor, F.; Fernandez, N.; Baldi, A.; De Kimpe, N.; Rossi, J.; Debenedetti, S.; Davio, C. Cancer Lett. 2004, 210, 179-188]. These promising findings prompted us to investigate the anti-leukemia activity of a broader range of related polyoxygenated coumarins. Twenty related natural or synthetically prepared coumarins, including a range of 5-substituted ayapin derivatives which have become easy accessible via newly developed synthesis methods, were evaluated, where treatments with 5-(2,3-dihydroxy-3-methylbutoxy)-6,7-methylenedioxycoumarin (D-3) and 5-(2-hydroxy-3-methoxy-3-methylbutoxy)-6,7-methylenedioxycoumarin (D-2) were able to inhibit the cell growth and induce the differentiation of U-937 cells after 48 h treatment. These results provide insight into the correlation between some structural properties of polyoxygenated coumarins and their in vitro leukemic differentiation activity.