964-26-1

Basic information

• Product Name: 5'-Uridylic acid,2'-deoxy-
• Synonyms: Uridine,2'-deoxy-, 5'-(dihydrogen phosphate) (8CI); Uridine, 2'-deoxy-, 5'-phosphate(6CI,7CI); 2'-Deoxy-5'-UMP; 2'-Deoxy-5'-uridylic acid; 2'-Deoxyuridine5'-monophosphate; 2'-Deoxyuridine 5'-phosphate; 2'-Deoxyuridylate;2'-Deoxyuridylic acid; Deoxy-UMP; Deoxyuridine 5'-monophosphate; Deoxyuridine5'-phosphate; dUMP
• CAS NO: 964-26-1
• Molecular Formula: C9H13 N2 O8 P
• Molecular Weight: 308.185
• EINECS: 213-518-9, 255-687-1
• Mol File: 964-26-1.mol
• Article Data: 8

Chemical Properties

• Appearance: white powder
• Water Solubility: Safety Data
  1. N/A
  2. N/A
  3. N/A
  6. UN NO.
  7. N/A
  8. 964-26-1(Hazardous Substances Data)
• HazardClass: UN NO.
• Hazardous Substances Data: 964-26-1(Hazardous Substances Data)

Usage

General Description

The chemical 5'-Uridylic acid, 2'-deoxy- is a modified form of uridylic acid, a nucleotide that serves as a building block of RNA. It is a derivative of uridine, which is a nucleoside composed of uracil and the sugar ribose. In this modified form, the sugar component is deoxyribose instead of ribose. This modification allows the chemical to be incorporated into DNA, where it can serve as a precursor for the synthesis of DNA. The presence of 5'-Uridylic acid, 2'-deoxy- can affect the structure and function of DNA and RNA molecules in biological systems.

Upstream product

• 23197-88-8 3'-O-acetyl-2'-deoxyuridine 
• 81049-55-0 C₉H₁₅N₄O₆P 
• 1032-65-1 cytidine 5'-(dihydrogen phosphate) 
• 951-78-0 2'-deoxyuridine 

Downstream Products

• 365-07-1 thymidine 5'-phosphate 
• 35959-38-7 5'-Amino-2',5'-dideoxy-uridine 
• 5238-86-8 5-(hydroxymethyl)-2′-deoxyuridine-5′-monophosphate 
• 1173-82-6 2'-deoxyuridine-5'-triphosphate 
• 4208-67-7 dUDP 

Relevant articles and documents

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Fully automated continuous meso-flow synthesis of 5′-nucleotides and deoxynucleotides

The first continuous meso-flow synthesis of natural and non-natural 5′-nucleotides and deoxynucleotides is described, representing a significant advance over the corresponding in-flask method. By means of this meso-flow technique, a synthesis with time consumption and high-energy consumption becomes facile to generate products with great efficiency. An abbreviated duration, satisfactory output, and mild reaction conditions are expected to be realized under the present procedure.

Two thymidine kinases and one multisubstrate deoxyribonucleoside kinase salvage DNA precursors in Arabidopsis thaliana

Deoxyribonucleotides are the building blocks of DNA and can be synthesized via de novo and salvage pathways. Deoxyribonucleoside kinases (EC 2.7.1.145) salvage deoxyribonucleosides by transfer of a phosphate group to the 5' of a deoxyribonucleoside. This salvage pathway is well characterized in mammals, but in contrast, little is known about how plants salvage deoxyribonucleosides. We show that during salvage, deoxyribonucleosides can be phosphorylated by extracts of Arabidopsis thaliana into corresponding monophosphate compounds with an unexpected preference for purines over pyrimidines. Deoxyribonucleoside kinase activities were present in all tissues during all growth stages. In the A. thaliana genome, we identified two types of genes that could encode enzymes which are involved in the salvage of deoxyribonucleosides. Thymidine kinase activity was encoded by two thymidine kinase 1 (EC 2.7.1.21)-like genes (AtTK1a and AtTK1b). Deoxyadenosine, deoxyguanosine and deoxycytidine kinase activities were encoded by a single AtdNK gene. T-DNA insertion lines of AtTK1a and AtTK1b mutant genes had normal growth, although AtTK1a AtTK1b double mutants died at an early stage, which indicates that AtTK1a and AtTK1b catalyze redundant reactions. The results obtained in the present study suggest a crucial role for the salvage of thymidine during early plant development. 2012 The Authors Journal compilation

Nucleosides for imaging and treatment applications

Methods of diagnosing and/or of treating tumors by administering a nucleoside analogue which is activated by thymidylate synthase and/or thymidine kinase enzyme into a diagnostic or toxic metabolite, and uridine analogue compounds, and compositions of same having a pharmaceutically acceptable carrier. For diagnostic applications, compounds containing a label and methods of use of such compounds are described.