959763-06-5 Usage
Description
CH5138303 is a triazine Hsp90 inhibitor that binds to the N-terminus of Hsp90α with high affinity (Kd = 0.52 nM) and exhibits potent inhibitory effects on the growth of various human tumor cell lines in vitro, as well as in vivo in gastric cancer xenografts. Its high oral bioavailability in mice makes it a promising candidate for further development as a cancer therapeutic agent.
Uses
Used in Pharmaceutical Industry:
CH5138303 is used as a cancer therapeutic agent for its ability to inhibit the growth of human tumor cell lines, such as HCT116 and NCI-N87, in vitro with low IC50 values (89 and 66 nM, respectively). Its efficacy is further demonstrated in vivo through the inhibition of human NCI-N87 gastric cancer xenografts in mice, with an ED50 of 3.9 mg/kg.
Additionally, CH5138303's high oral bioavailability in mice suggests its potential for use in the development of oral cancer treatments, which could improve patient compliance and quality of life. Further research and development are needed to optimize its therapeutic potential and explore its applicability in various cancer types.
references
[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.
Check Digit Verification of cas no
The CAS Registry Mumber 959763-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,5,9,7,6 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 959763-06:
(8*9)+(7*5)+(6*9)+(5*7)+(4*6)+(3*3)+(2*0)+(1*6)=235
235 % 10 = 5
So 959763-06-5 is a valid CAS Registry Number.
