956830-72-1

Basic information

• Product Name: N-[(E)-dec-2-enoyl]morpholine
• Synonyms: N-[(E)-dec-2-enoyl]morpholine
• CAS NO: 956830-72-1
• Molecular Weight: 239.358
• Mol File: 956830-72-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-[(E)-dec-2-enoyl]morpholine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-dec-2-enoyl]morpholine(956830-72-1)
• EPA Substance Registry System: N-[(E)-dec-2-enoyl]morpholine(956830-72-1)

Safety Data

• Hazardous Substances Data: 956830-72-1(Hazardous Substances Data)

Upstream product

• 39205-49-7 2,2-dichloro-1-morpholinoethan-1-one 
• 124-13-0 Octanal 

Downstream Products

• 3913-81-3 (E)-2-decenal 
• 334-49-6 trans-2-decenoic acid 

Relevant articles and documents

TRANS-2-DECENOIC ACID DERIVATIVE AND DRUG CONTAINING SAME

The present invention relates to a novel trans-2-decenoic acid derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical agent containing the compound as an active ingredient. The trans-2-decenoic acid derivative or a pharmaceutically acceptable salt, which is the compound of the present invention, is specifically represented by the general formula (I): wherein X is a substituent such as a 1-pyrrolidyl, a 3-thiazolizyl, or a piperidino, and the compound is highly useful as a pharmaceutical agent, such as a prophylactic or therapeutic agent for a peripheral nerve disorder induced by administration of an anticancer agent, a prophylactic or therapeutic agent for neurodegenerative diseases or mental diseases such as dementia, Alzheimer's diasease, Parkinson's disease, diabetic neuropathy, depression, glaucoma, or autistic disorder spectrum, a therapeutic or repairing agent for spinal cord injury, analgesics against various pain diseases, or the like.

Sequential reactions promoted by manganese: Completely stereoselective synthesis of (E)-α,β-unsaturated amides, ketones, aldehydes, and carboxylic acids

(Chemical Equation Presented) A complete E-selective synthesis of α,β-unsaturated amides through a sequential reaction of a range of dichloroamides with a variety of aldehydes promoted by Rieke manganese (Mn*) is reported. A mechanism based on a sequential aldol-type reaction and a completely stereoselective β-elimination is proposed to explain these results. The unsaturated amides obtained are readily and efficiently transformed into α,β-unsaturated ketones, aldehydes, or carboxylic acids without loss of the diastereoisomeric purity of the C-C double bond.