952340-40-8

Basic information

• Product Name: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate
• Synonyms: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate
• CAS NO: 952340-40-8
• Molecular Weight: 531.626
• Mol File: 952340-40-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate(952340-40-8)
• EPA Substance Registry System: 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate benzene sulfonate(952340-40-8)

Safety Data

• Hazardous Substances Data: 952340-40-8(Hazardous Substances Data)

Upstream product

• 951380-43-1 2-oxo-2,4,5,6,7a-hexahydrothieno[3,2-c]pyridine hydrochloride 
• 1100905-46-1 3-cyclopropyl-1-(2-fluorophenyl)-3-oxopropyl methanesulfonate 
• 178688-49-8 5,6,7,7a-tetrahydro-4H-thieno[3,2-c]pyridin-2-one p-toluenesulfonate 
• 204205-33-4 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone 
• 98-11-3 benzenesulfonic acid 
• 150322-43-3 prasugel 

Relevant articles and documents

METHOD OF PRODUCING HIGHLY PURE PRASUGREL AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

A method for the production of 5-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]- 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-yl acetate of formula (I) or its salts, characterized in that the compound of formula (III) in the form of a salt with an arene sulfonic acid is reacted with the compound of formula (XV), wherein Y means: chlorine, bromine, or an OR4 group, wherein R4 means an alkane sulfonic group or arene sulfonic group, in an organic solvent in the presence of an inorganic base or organic base, to give, after addition of an acetylating reagent and organic base to the reaction mixture, the compound of formula (I), which, after addition of a co-solvent, is crystallized from the reaction mixture, and the compound of formula (I) is optionally purified by crystallization and optionally converted to a salt by reaction with an organic or inorganic acid in a suitable solvent. (Formulae (I), (III), (XV)

ACID ADDITION SALTS OF PRASUGREL AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME

The invention relates to acid addition salts of Prasugrel, a process for their preparation and pharmaceutical compositions comprising the same. In particular the application relates to salts of Prasugrel with benzenesulfonic and naphthalinesulfonic acids.

IMPROVED PROCESS FOR THE PREPARATION OF PRASUGREL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS

The present invention relates to an improved process for the preparation of prasugrel compound of formula- 1 and its pharmaceutically acceptable salts thereof.