951010-96-1Relevant articles and documents
Design, synthesis, and biological evaluation of tricyclic heterocycle-tetraamine conjugates as potent NMDA channel blockers
Takayama, Hiromitsu,Yaegashi, Yuichi,Kitajima, Mariko,Han, Xia,Nishimura, Kazuhiro,Okuyama, Shigeru,Igarashi, Kazuei
, p. 4729 - 4732 (2008/03/11)
We have developed a new class of N-methyl-d-aspartate (NMDA) channel blockers having a conjugate structure that consists of a nitrogenous heterocyclic head and a tetraamine tail. Among them, dihydrodibenzazepine-homospermine conjugate (8) exhibited potent