94527-74-9

Basic information

• Product Name: TRIETHYLAMINE PENTAHYDROFLUORIDE
• Synonyms: TRIETHYLAMINE PENTAHYDROFLUORIDE;Tris(ethyl)amine pentahydrofluoride
• CAS NO: 94527-74-9
• Molecular Formula: C6H20F5N
• Molecular Weight: 201.22
• Product Categories: Fluorinating Reagents;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Fluorination;Halogenation;Nucleophilic Fluorinating Reagents;Synthetic Organic Chemistry
• Mol File: 94527-74-9.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: TRIETHYLAMINE PENTAHYDROFLUORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYLAMINE PENTAHYDROFLUORIDE(94527-74-9)
• EPA Substance Registry System: TRIETHYLAMINE PENTAHYDROFLUORIDE(94527-74-9)

Safety Data

• Statements: 26/27/28-35
• Safety Statements: 7-9-26-37/39-45
• RIDADR: 1790
• Hazardous Substances Data: 94527-74-9(Hazardous Substances Data)

Usage

General Description

Triethylamine pentahydrofluoride is a chemical compound that consists of a pentahydrofluoride salt of triethylamine, an organic compound with the formula C6H15N. It is a colorless liquid with a strong odor, and it is highly soluble in water. Triethylamine pentahydrofluoride is commonly used as a catalyst and a deprotection reagent in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It is also used as an intermediate in the production of other chemicals. However, it is important to handle this compound with care, as it is highly corrosive and can be toxic if ingested or inhaled.

Upstream product

• 2062-98-8 perfluoro(2-propoxypropionyl) fluoride 
• 76-37-9 2,2,3,3-tetrafluoropropanol 
• 422-61-7 perfluoropropanoyl fluoride 
• 375-84-8 2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptanoyl fluoride 
• 23588-89-8 triethylammonium dihydrofluoride 
• 121-44-8 triethylamine 
• 376-90-9 2,2,3,3,4,4-hexafluoro-1,5-pentanediol 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 307-30-2 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-1-octanol 
• 307-70-0 1H,1H,11H-trihydroperfluoro-1-undecanol 
• 560-16-7 2,2,3,3-tetrafluoro-3-(trifluoromethoxy)propan-1-ol 
• 335-99-9 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-1-heptanol 
• 376-18-1 1H,1H,9H-hexadecafluoro-1-nonanol 
• 355-80-6 2,2,3,3,4,4,5,5-octafluoropentan-1-ol 

Downstream Products

• 144717-69-1 trans-[Pt(H)(F)(PCy₃)2] 
• 929904-84-7 guadecitabine triethylammonium salt 
• 1624605-95-3 benzyl 4-(difluoromethyl)piperidine-1-carboxylate 
• 1388651-17-9 N-((4aS,5S,7aS)-7a-(2,3-difluorophenyl)-5-(fluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide 
• 155145-20-3 (fluorido)(5,10,15,20-tetramesitylporphyrinato)iron(III) 
• 869749-35-9 [(PdMe)2(μ-κ2(P,P)Cy2PCH2PCy2)2(μ-F)][FHF] 

Relevant articles and documents

Iron(II)-Catalyzed Intermolecular Aminofluorination of Unfunctionalized Olefins Using Fluoride Ion

We herein report a new catalytic method for intermolecular olefin aminofluorination using earth-abundant iron catalysts and nucleophilic fluoride ion. This method tolerates a broad range of unfunctionalized olefins, especially nonstyrenyl olefins that are incompatible with existing olefin aminofluorination methods. This new iron-catalyzed process directly converts readily available olefins to internal vicinal fluoro carbamates with high regioselectivity (N vs F), many of which are difficult to prepare using known methods. Preliminary mechanistic studies demonstrate that it is possible to exert asymmetric induction using chiral iron catalysts and that both an iron-nitrenoid and carbocation species may be reactive intermediates.

ANTISENSE MODULATION OF STEAROYL-COA DESATURASE EXPRESSION

Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.

Antisense modulation of CD36 expression

Antisense compounds, compositions and methods are provided for modulating the expression of CD36. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CD36. Methods of using these compounds for modulation of CD36 expression and for treatment of diseases associated with expression of CD36 are provided.