944529-34-4

Basic information

• Product Name: C₁₆H₁₂BrClN₂O₃
• Synonyms: C₁₆H₁₂BrClN₂O₃
• CAS NO: 944529-34-4
• Molecular Weight: 395.64
• Mol File: 944529-34-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₂BrClN₂O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₂BrClN₂O₃(944529-34-4)
• EPA Substance Registry System: C₁₆H₁₂BrClN₂O₃(944529-34-4)

Safety Data

• Hazardous Substances Data: 944529-34-4(Hazardous Substances Data)

Upstream product

• 14426-42-7 ethyl p-chlorophenoxyacetate 
• 122-88-3 4-Chlorophenoxyacetic acid 
• 106-48-9 4-chloro-phenol 
• 1878-91-7 (4-bromophenoxy)acetic acid 
• 2381-75-1 (4-chlorophenoxy)acetic acid hydrazide 

Relevant articles and documents

Synthesis and evaluation of antibacterial and antifungal activities of some novel 2,5-disubstituted-1,3,4-oxadiazoles

4-Chlorophenoxy acetic acid 2 was prepared by the condensation of phenol with monochloroacetic acid. Compound 2 was refluxed with ethanol in the presence of HCI gas yielding ethyl (4-chlorophenoxy) acetate 3. Compound 3 was refluxed with hydrazine hydrate in ethanol which produced 2-(4-chlorophenoxy) acetohydrazide 4. Compound 5a was synthesized by refluxing 2-(4-chlorophenoxy) acetohydrazide 4 with carbon disulfide and KOH in the presence of ethanol. Compound 5a on condensation with pbenzoquinone yielded 2-({4-[(4-chlorophenoxy) methyl]-1,3-4-oxadiazole-2-yl} sulfanyl) benzene-1,4-diol 5b. Oxadiazoles 6a-d were prepared by reacting substituted phenoxy acetic acids with 2-(4-chlorophenoxy) acetohydrazide 4 in the presence of POCI3. Further Schiff bases were synthesized by the reaction of substituted aldehydes with 2-(4-chlorophenoxy) acetohydrazide 4 in presence of ethanol. These Schiff bases on reaction with acetic anhyd gave the corresponding 3-acetyl-2,3-dihydro 1,3,4-oxadiazoles 7ad. Synthesized compounds were characterized on the basis of spectral and analytical data. All the compounds were screened for antimicrobial activity.