942195-01-9

Basic information

• Product Name: tert-butyl (R)-3-(4-iodophenoxy)pyrrolidine-1-carboxylate
• Synonyms: tert-butyl (R)-3-(4-iodophenoxy)pyrrolidine-1-carboxylate
• CAS NO: 942195-01-9
• Molecular Weight: 389.233
• Mol File: 942195-01-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl (R)-3-(4-iodophenoxy)pyrrolidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (R)-3-(4-iodophenoxy)pyrrolidine-1-carboxylate(942195-01-9)
• EPA Substance Registry System: tert-butyl (R)-3-(4-iodophenoxy)pyrrolidine-1-carboxylate(942195-01-9)

Safety Data

• Hazardous Substances Data: 942195-01-9(Hazardous Substances Data)

Upstream product

• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 540-38-5 p-Iodophenol 
• 132945-75-6 (S)-tert-butyl 3-(methylsulfonyloxy)pyrrolidine-1-carboxylate 
• 109431-87-0 (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate 

Downstream Products

• 1220019-06-6 (R)-3-(4-iodophenoxy)pyrrolidine hydrochloride 
• 942195-03-1 (R)-3-[4-(4-Chloro-phenoxy)-phenoxy]-pyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

BIARYL SUBSTITUTED NITROGEN CONTAINING HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION

The present invention relates to a chemical genus of biaryl substituted nitrogen-attached heterocycles that are inhibitors of LTA4H (leukotriene A4 hydrolase). The compounds have the general formula: They are useful for the treatment and prevention and pr