942183-80-4 Usage
Description
SCH772984 is a potent and selective inhibitor of extracellular regulated kinases 1 and 2 (ERK1/2), which are functionally redundant kinases activated by various growth factors and mitogens. It exhibits both type I and type II kinase inhibitor behaviors and has nanomolar cytotoxicity in tumor cells with mutations in BRAF, NRAS, or KRAS. SCH772984 is effective in inducing tumor regressions in xenograft models and displays slow binding kinetics, binding to a novel binding pocket in inactive ERK isoforms.
Uses
Used in Oncology:
SCH772984 is used as an anticancer agent for targeting tumor cells with mutations in BRAF, NRAS, or KRAS. Its high selectivity and potency make it a promising candidate for treating various types of cancer.
Used in Drug Development:
SCH772984 is used as a research tool for studying the role of ERK1/2 in cell signaling pathways and for developing novel therapeutic strategies targeting these kinases. Its unique binding properties and slow binding kinetics provide valuable insights into the development of new drugs with improved efficacy and selectivity.
Used in Cancer Research:
SCH772984 is used as a valuable compound in cancer research to investigate the mechanisms of action and resistance to ERK1/2 inhibitors. Its ability to induce tumor regressions in xenograft models makes it an important tool for understanding the therapeutic potential of targeting ERK1/2 in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 942183-80-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,2,1,8 and 3 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 942183-80:
(8*9)+(7*4)+(6*2)+(5*1)+(4*8)+(3*3)+(2*8)+(1*0)=174
174 % 10 = 4
So 942183-80-4 is a valid CAS Registry Number.
