940929-33-9 Usage
Description
SB 743921 Hydrochloride is a mitotic kinesin inhibitor, a type of small molecule compound that targets and inhibits the function of mitotic kinesins, essential proteins involved in cell division. SB 743921 has the potential to disrupt the process of mitosis, leading to the inhibition of cell proliferation and has been studied for its therapeutic effects in various diseases.
Uses
Used in Pharmaceutical Industry:
SB 743921 Hydrochloride is used as a mitotic kinesin inhibitor for its potential therapeutic effects in treating diseases characterized by abnormal cell proliferation, such as cancer.
Used in Lung Disease Treatment:
In the context of lung diseases, SB 743921 Hydrochloride is used as an adjunct therapy in combination with other treatments to target the abnormal cell division that may contribute to the progression of lung diseases, potentially leading to improved patient outcomes.
Biological Activity
sb743921 is an inhibitor of kinesin spindle protein (ksp) with ki value of 0.1nm [1].as an inhibitor of mitotic kinesin ksp, sb743921 causes cell cycle arrest in mitosis, results in cell death. sb743921 is developed to treat for cancers. sb743921 is a potent and selective inhibitor. in the affinity assays, sb743921 shows ki values of 0.1nm and 0.12nm for human ksp and mouse ksp, respectively. it has no affinity with other kinesins. in the cellular assay, sb743921 exerts anti-proliferation efficacy in skov3, colo205, mv522 and mx1 with ic50 values of 0.02nm, 0.07nm, 1.7nm and 0.06nm. moreover, sb743921 is shown to have activity against human tumor xenografts colo205, mcf-7, sk-mes, h69, ovcar-3, ht-29, mda-mb-231 and a2780. sb743921 is also effective against p388 lymphocytic leukemia xenografts in mice [1].
references
[1] jackson j r, gilmartin a, dhanak d, et al. a second generation ksp inhibitor, sb-743921, is a highly potent and active therapeutic in preclinical models of cancer. proceedings of the american association for cancer research, 2006, 2006(2): b11.
Check Digit Verification of cas no
The CAS Registry Mumber 940929-33-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,4,0,9,2 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 940929-33:
(8*9)+(7*4)+(6*0)+(5*9)+(4*2)+(3*9)+(2*3)+(1*3)=189
189 % 10 = 9
So 940929-33-9 is a valid CAS Registry Number.