936630-57-8Relevant articles and documents
Preparation method of 1-morpholinyl-4-(2,4,5-trifluorophenyl)butane-1,3-dione
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, (2020/05/02)
The invention discloses a preparation method of 1-morpholinyl-4-(2,4,5-trifluorophenyl)butane-1,3-dione, and belongs to the technical field of organic synthesis. The preparation method comprises the following step: under the action of a metal chelating agent and an alkali, carrying out a reaction of the following formula on a compound 2 and a compound 3 in an organic solvent to obtain a compound 1. The preparation method disclosed by the invention is high in yield, simple in post-treatment, simple, feasible, mild in reaction condition and suitable for industrial production.
A west geleg sandbank intermediate biological synthesis method (by machine translation)
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, (2019/07/04)
The invention discloses a west geleg sandbank intermediate biological synthesis method, namely in order to 4 - (2, 4, 5 - trifluoro methyl) uracil as the substrate under the action, by the one-pot preparation, Or, 4 - (2, 4, 5 - trifluoro methyl) uracil enzyme preparation obtained the situation that the (R)- 3 - carbamoyl amino - 4 - (2, 4, 5 - trifluorophenyl) butanoic acid, after separation, then the role of the enzyme or acid producing the (R)- 3 - amino - 4 - (2, 4, 5 - trifluorophenyl) butanoic acid, The west geleg sandbank intermediate the biological synthesis of simple process, without special request to device, to obtain a high EE value of the product, is suitable for industrial production. (by machine translation)
Glutamate as an Efficient Amine Donor for the Synthesis of Chiral β- and γ-Amino Acids Using Transaminase
Kim, Geon-Hee,Jeon, Hyunwoo,Khobragade, Taresh P.,Patil, Mahesh D.,Sung, Sihyong,Yoon, Sanghan,Won, Yumi,Sarak, Sharad,Yun, Hyungdon
, p. 1437 - 1440 (2019/02/06)
A recyclable glutamate amine donor system employing transaminase (TA), glutamate dehydrogenase (GluDH) and mutant formate dehydrogenase (FDHm) was developed, wherein amine donor Glu was regenerated using GluDH and thereby circumvented the inhibition of TA by α-ketoglutarate. Various enantiopure β-, γ-amino acids, and amines were successfully synthesized with high conversions and excellent enantiomeric excess using this system.