93-61-8 Usage
Description
N-Methylformanilide, also known as N-methyl-o-toluidine, is an organic compound that serves as an important intermediate in the synthesis of various organic and organometallic compounds. It is characterized by its ability to act as a formylating agent and a swelling agent in specific applications.
Uses
Used in Organic Synthesis:
N-Methylformanilide is used as a formylating reagent for certain organometallics, playing a crucial role in the synthesis of complex organic molecules. Its reactivity and stability make it a valuable component in the formation of desired products.
Used in Vilsmeier-Haack Reactions:
In the field of organic chemistry, N-Methylformanilide is utilized in combination with phosphoryl chloride for Vilsmeier-Haack reactions. This reaction is an efficient method for the synthesis of formyl derivatives, which are essential building blocks in the preparation of various organic compounds.
Used in Heterocycle Syntheses:
N-Methylformanilide also finds application in the synthesis of heterocycles, which are compounds containing a ring structure with at least one heteroatom. Its ability to formylating agents makes it a useful component in the creation of these diverse and important classes of compounds.
Used in Textile Industry:
In the dyeing process of meta-aramid fibers, N-Methylformanilide acts as a swelling agent. This application is crucial for enhancing the dye uptake and improving the overall quality of the finished product, making it an essential component in the textile industry.
Flammability and Explosibility
Notclassified
Check Digit Verification of cas no
The CAS Registry Mumber 93-61-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 93-61:
(4*9)+(3*3)+(2*6)+(1*1)=58
58 % 10 = 8
So 93-61-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H9NO/c1-9(7-10)8-5-3-2-4-6-8/h2-7H,1H3
93-61-8Relevant articles and documents
-
Fieser,Jones
, p. 66 (1940)
-
Catalyst-free photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines
Duan, Wentao,Lian, Qi,Wang, Songping,Wei, Wentao,Zhou, Jingwei
supporting information, p. 3261 - 3267 (2021/05/21)
Due to the directional nature of sp3-hybridized orbitals and the absence of π-orbitals, the oxidative cleavage of the kinetically and thermodynamically stable C(sp3)-C(sp3) bond is extremely difficult and remains scarcely explored. In this work, under the double argument of quantum mechanics (QM) computations and meticulous experiments on our well-designed C-C single bond cleavage mechanism, we discovered a means of photoinduced selective oxidative C(sp3)-C(sp3) bond cleavage in arylamines, easily achieved by simple visible light irradiation using O2as a benign oxidant under very mild conditions. The utility of our methodology was demonstrated by the C(sp3)-C(sp3) bond cleavage in morpholine/piperazine arylamines with excellent functional group tolerance. Importantly, our methodology is noteworthy, not only in that it does not require any catalysts, but also in that it provides valuable possibilities for the scalable functionalization of clinical drugs and natural products.
N-formylation of amines using phenylsilane and CO2 over ZnO catalyst under mild condition
Cheng, Yujie,Gan, Tao,He, Qian,He, Xiaohui,Ji, Hongbing,Sun, Qingdi,Wang, Pengbo,Zhang, Hao
, (2020/10/27)
Several research studies have been conducted on N-formylation of amines using phenylsilane and CO2. However, most of these studies involved tedious processes of catalyst preparation or complex procedures. In the present study, we describe the use of a simple and commercially available ZnO catalyst for selective N-formylation of amines under mild condition. High-yielding N-formylation products with good recyclability and wide substrate scope were obtained, which can promote fine chemical synthesis and CO2 capture.