924663-40-1

Basic information

• Product Name: Rabeprazole Sulfide N-Oxide
• Synonyms: Rabeprazole Sulfide N-Oxide;2-[[[4-(3-Methoxypropoxy)-3-Methyl-1-oxido-2-pyridinyl]Methyl]thio]-1H-benziMidazole;RaBeprazole Impurity 10;Rabeprazole Impurity 14;Rabeprazolesodium Impurity T
• CAS NO: 924663-40-1
• Molecular Formula: C₁₈H₂₁N₃O₃S
• Molecular Weight: 358.4347
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 924663-40-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 149-150 °C(Solv: acetone (67-64-1))
• Boiling Point: 637.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.50±0.10(Predicted)
• CAS DataBase Reference: Rabeprazole Sulfide N-Oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Rabeprazole Sulfide N-Oxide(924663-40-1)
• EPA Substance Registry System: Rabeprazole Sulfide N-Oxide(924663-40-1)

Safety Data

• Hazardous Substances Data: 924663-40-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Rabeprazole Sulfide N-Oxide (cas# 924663-40-1) is a compound useful in organic synthesis.

Upstream product

• 924663-39-8 2-chloromethyl-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide 
• 134469-07-1 Benzimidazol-2-thiol 

Downstream Products

• 924663-38-7 2-[[(RS)-(1H-benzimidazol-2-yl)sulfinyl]methyl]-4-(3-methoxypropoxy)-3-methylpyridine 1-oxide 
• 924663-37-6 2-[(4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl-1-oxide)methylsulfonyl]-1H-benzoimidazole 
• 117976-89-3 rabeprazole 

Relevant articles and documents

Synthesis of metabolites and related substances of rabeprazole, an anti-ulcerative drug

Rabeprazole sodium (Aciphex) is a gastric proton pump inhibitor used for the prevention and treatment of gastric acid-related diseases. During the synthesis of bulk drug of rabeprazole sodium, we have observed metabolites rabeprazole sulfide and rabeprazole sulfone and related substances rabeprazole-N-oxide, rabeprazole sulfone-N-oxide, N-aralkyl rabeprazole, chloro rabeprazole, and methoxy rabeprazole as impurities in the drug substance. The present work describes the synthesis and characterization of these compounds. Copyright Taylor & Francis Group, LLC.

Synthetic studies connected with the preparation of H+/K +-ATPase inhibitors rabeprazole and lansoprazole

Synthesis of lansoprazole and rabeprazole using common intermediates is devised. The common intermediates, 2-[(4-nitro-3-methylpyridin-2-yl) methanesulfanyl]-1H-benzoimidazole and 2-[(4-chloro-3-methyl-pyridin-2-yl) methanesulfanyl]-1H-benzoimidazole, were prepared in several ways.