92260-81-6

Basic information

• Product Name: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione
• Synonyms: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione ;8,9-dihydro-2H,7H-2,9a-diaza-benzo[cd]azulene-1,6-dione;5,6-Dihydro-iMidazo[4,5,l...;5,6-Dihydro-iMidazo[4,5,l-j-k][1]benzazepine-2,7-[1H,4H]-dione;IMidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione, 5,6-dihydro;InterMediates of Zilpaterol;8,9-Dihydro-2,9a-diazabenzo[cd]azulene-1,6(2H,7H)-dione
• CAS NO: 92260-81-6
• Molecular Formula: C₁₁H₁₀N₂O₂
• Molecular Weight: 202.2093
• Product Categories: azulene;Aromatics;Heterocycles
• Mol File: 92260-81-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.26±0.20(Predicted)
• CAS DataBase Reference: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(92260-81-6)
• EPA Substance Registry System: 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione(92260-81-6)

Safety Data

• Hazardous Substances Data: 92260-81-6(Hazardous Substances Data)

Usage

Description

5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is a pale yellow solid compound with a unique chemical structure that makes it valuable in various organic synthesis applications.

Uses

Used in Organic Synthesis:
5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is used as a key intermediate in the synthesis of various organic compounds. Its unique structure allows it to be a versatile building block for the development of new molecules with potential applications in pharmaceuticals, agrochemicals, and other industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is used as a starting material for the synthesis of novel drug candidates. Its chemical properties enable the creation of diverse molecular structures with potential therapeutic effects.
Used in Agrochemical Industry:
5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its unique structure can contribute to the development of more effective and environmentally friendly products.
Used in Research and Development:
In research and development, 5,6-Dihydroimidazo[4,5,1-jk][1]benzazepine-2,7(1H,4H)-dione serves as a valuable compound for exploring new chemical reactions and synthetic pathways. Its properties can provide insights into the development of innovative synthetic methods and strategies.

Upstream product

• 52099-78-2 4-(3-isopropenyl-2-oxo-2,3-dihydro-benzoimidazol-1-yl)-butyric acid 
• 116199-87-2 ethyl 2,3-dihydro-3-(1-methyl-ethenyl)-2-oxo-1H-benzimidazol-1-butanoate 
• 95-54-5 1,2-diamino-benzene 
• 52099-72-6 1,3-dihydro-1-(1-methylethenyl)-2H-benzimidazol-2-one 
• 1021910-67-7 chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate 
• 3273-68-5 4-(1,2-dihydro-2-oxobenzo[d]imidazole-3-yl)butanoic acid 

Downstream Products

• 92260-82-7 4,5,6,7-tetrahydro-6-hydroxyimino-imidazo[4,5,1-jk]-[1]-benzazepine-2,7(1H,6H)-dione 
• 1019768-88-7 (6R,7R)-7-hydroxy-6-{[(R)-3-(2-hydroxyphenyl)-1-methylpropyl]amino}-4,5,6,7-tetrahydroimidazo[4,5,1-jk][1]benzazepin-2(1H)-one 

Relevant articles and documents

Method for preparing 2, 3-dihydro-2-oxo-1H-benzimidazole-1-butyric acid

The invention relates to a method for preparing 2, 3-dihydro-2-oxo-1H-benzimidazole-1-butyric acid, which comprises the following steps of: dehydrating 1, 3-dihydro-1-(1-methylvinyl)-2H-benzimidazole-2-one in an organic solvent at 100-120 DEG C under the action of an acid-binding agent, adding ethyl 4-bromobutyrate for reaction after dehydration, cooling the reaction liquid to 70-90 DEG C after the reaction is finished, adding water preheated to 40-60 DEG C, stirring and splitting phases at proper time; and adding alkali into an organic phase, carrying out saponification reaction under the environment of 45-80 DEG C and 150-200 mbar, slowly adding hydrochloric acid at the temperature of 40-60 DEG C after the saponification reaction is finished, then reacting for 2-4 hours at the temperature of 90-110 DEG C, cooling, filtering, washing a filter cake with water, and drying the filter cake to constant weight at 50-70 DEG C and 100-180 mbar. Potassium carbonate is used to replace sodium hydride, so that the problems of high potential safety hazard, serious three-waste pollution and the like in the traditional process are fundamentally eliminated, the production process is simpler and more convenient by frying in one pot, and the production cost is reduced; and meanwhile, the method is simple, convenient and safe to operate, reasonable in process condition, high in reaction yield and relatively high in implementation value.

PROCESS FOR MAKING A CRYSTALLINE ZILPATEROL SALT

This invention generally relates to processes for making a crystalline zilpaterol salt, particularly zilpaterol hydrochloride. This invention also relates to methods of treatment using a crystalline zilpaterol salt prepared in accordance with this invention to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.

PROCESSES FOR MAKING ZILPATEROL AND SALTS THEREOF

This invention generally relates to processes for making zilpaterol and salts thereof, as well as processes for making intermediates that, inter alia, may be used to make zilpaterol and salts thereof. The zilpaterol and salts prepared in accordance with this invention can be used to increase the rate of weight gain, improve feed efficiency, and/or increase carcass leanness in livestock, poultry, and fish.