918523-76-9

Basic information

• Product Name: 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester
• Synonyms: 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester
• CAS NO: 918523-76-9
• Molecular Weight: 275.301
• Mol File: 918523-76-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester(918523-76-9)
• EPA Substance Registry System: 2-fluoro-3-(propane-1-sulfonylamino)-benzoic acid methyl ester(918523-76-9)

Safety Data

• Hazardous Substances Data: 918523-76-9(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 57946-56-2 2-fluoro-4-chloroaniline 
• 918523-47-4 benzyl 6-chloro-2-fluoro-3-(propylsulfonamido)benzoate 
• 918523-48-5 6-chloro-2-fluoro-3-(propane-1-sulfonamido)benzoic acid 
• 918523-46-3 benzyl 2-fluoro-3-amino-6-chlorobenzoate 
• 918523-49-6 2-fluoro-3-(propylsulfonamido)benzoic acid 
• 317-46-4 2-fluoro-3-nitro-benzoic acid 
• 437-86-5 2-fluoro-3-nitrotoluene 
• 10147-36-1 n-propanesulfonyl chloride 
• 1195768-18-3 3-amino-2-fluorobenzoic acid methyl ester 
• 206551-41-9 2-fluoro-3-bromobenzoic acid methyl ester 
• 946126-94-9 2-fluoro-3-nitrobenzoic acid methyl ester 
• 161957-56-8 3-bromo-2-fluorobenzoic acid 

Downstream Products

• 918523-77-0 propane-1-sulfonic acid (2-fluoro-3-hydroxymethyl-phenyl)-amide 
• 1307271-90-4 N-{3-[(2-chloro-4-pyrimidinyl)acetyl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307272-05-4 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307272-22-5 1,1-dimethylethyl 4-(5-(2-chloro-4-pyrimidinyl)-4-{2-fluoro-3-[(propylsulfonyl)amino]phenyl}-1,3-thiazol-2-yl)-1-piperazinecarboxylate 
• 1307272-37-2 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307270-50-3 N-{2-fluoro-3-[5-(2-{[2-(1-pyrrolidinyl)ethyl]amino}-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide 
• 1307270-52-5 N-{3-[5-(2-amino-4-pyrimidinyl)-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307270-79-6 N-{2-fluoro-3-[5-{2-[(2-cyanoethyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide 
• 1307271-15-3 N-{2-fluoro-3-[5-{2-[(2-hydroxy-2-methylpropyl)amino]-4-pyrimidinyl}-2-(tetrahydro-2H-pyran-4-yl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide 
• 1307271-58-4 N-{3-[5-(2-amino-4-pynmidinyl)-2-(1-piperazinyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307271-61-9 N-{2-fluoro-3-[5-(2-{[(2S)-2-hydroxypropyl]amino}-4-pyrimidinyl)-2-(4-methyl-1-piperazinyl)-1,3-thiazol-4-yl]phenyl}-1-propanesulfonamide 
• 1307272-84-9 N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-oxazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 1307271-75-5 N-{3-[5-(2-amino-4-pyrimidinyl)-2-(4-methyltetrahydro-2H-pyran-4-yl)-1,3-oxazol-4-yl]-2-fluorophenyl}-1-propanesulfonamide 
• 918523-78-1 propane-1-sulfonic acid (2-fluoro-3-formyl-phenyl)-amide 

Relevant articles and documents

BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS

The present invention provides thiazole sulfonamide and oxazole sulfonamide compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.

PYRROLO [2, 3-B] PYRIDINE DERIVATIVES FOR THE INHIBITION OF RAF KINASES

Propane-1-sulfonic acid {2,4-difluoro-3-[5-(2-methoxy-pyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-phenyl}-amide, propane-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, propane-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2-fluoro-phenyl]-amide, N-[3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-2,5-difluoro-benzenesulfonamide, N-[3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-3-fluoro-benzenesulfonamide, pyrrolidine-1-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, N,N-dimethylamino-sulfonic acid [3-(5-cyano-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]-amide, and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on at least one Raf protein kinase. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of Raf protein kinases, including melanoma, glioma, colorectal cancer, thyroid cancer, lung cancer, ovarian cancer, prostate cancer, and biliary tract cancer.

PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.