915095-99-7 Usage
Description
(1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol is a complex organic compound with a unique chemical structure. It is a derivative of D-glucitol, a sugar alcohol, and features various functional groups, including acetoxy, chloro, and tetrahydrofuran moieties. (1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol exhibits a high degree of structural complexity and specificity, making it a potentially valuable molecule for various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
(1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol is used as a pharmaceutical intermediate for the synthesis of Empagliflozin, a medication used to treat type 2 diabetes. It serves as an Empagliflozin intermediate, playing a crucial role in the development and production of this therapeutic agent.
Used in Chemical Production Processes:
In the chemical industry, (1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol is utilized as a key intermediate in the synthesis of glucopyranosyl-substituted benzonitriles. These compounds are valuable for the preparation of therapeutic agents that target metabolic disorders, offering potential treatments for various conditions related to metabolic dysfunction.
Used in Laboratory Research and Development:
(1S)-1,5-anhydro-2,3,4,6-tetra-O-acteyl-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydrofu-ran-3-yl]oxy]phenyl] methyl]phenyl]-D-Glucitol is also employed in laboratory research and development processes. Its unique chemical structure and properties make it an interesting candidate for further investigation and potential applications in various fields, such as drug discovery, material science, and chemical synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 915095-99-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,5,0,9 and 5 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 915095-99:
(8*9)+(7*1)+(6*5)+(5*0)+(4*9)+(3*5)+(2*9)+(1*9)=187
187 % 10 = 7
So 915095-99-7 is a valid CAS Registry Number.
915095-99-7Relevant articles and documents
Synthetic method of empagliflozin
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, (2021/07/24)
The invention belongs to the technical field of raw material medicine preparation, and relates to a synthetic method of an SGLT-2 inhibitor empagliflozin, which comprises the following steps: 1) taking glucose as an initial raw material, and preparing an active intermediate 3 through full acylation, selective hydrolysis and esterification; 2) reacting the intermediate 3 with chlorobenzene under the catalysis of boron trifluoride/diethyl ether to generate an intermediate 4, and reacting the intermediate 4 with paraformaldehyde and phenoxy tetrahydrofuran to generate an intermediate 5; and 3) removing the protecting group under the action of alkali to obtain the final product empagliflozin. The method is simple to operate, low-temperature reaction in the prior art is avoided, and the purity of the obtained product is higher.
Synthesizing method suitable for industrial empagliflozin production
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, (2019/10/17)
The invention discloses a synthesizing method suitable for industrial empagliflozin production. The synthesizing method includes: subjecting a compound as shown in formula (II) to reduction reaction to obtain a compound as shown in formula (I), and removing the protecting groups of the compound as shown in formula (I) to obtain empagliflozin. The synthesizing method has the advantages that the method is simple in process, only needs one-step reduction reaction and can effectively reduce the repeated use of high-toxicity and high-risk chemicals; in addition, the intermediate purified after derivation protection, effective process control is achieved, and product quality is increased; the method is high in practical application value and suitable for industrial production.
Nickel-catalyzed reductive coupling of glucosyl halides with aryl/vinyl halides enabling β-selective preparation of C-aryl/vinyl glucosides
Liu, Jiandong,Lei, Chuanhu,Gong, Hegui
, p. 1492 - 1496 (2019/07/05)
This work describes stereoselective preparation of β-C-aryl/vinyl glucosides via mild Ni-catalyzed reductive arylation and vinylation of C1-glucosyl halides with aryl and vinyl halides. A broad range of aryl halides and vinyl halides were employed to yield C-aryl/vinyl glucosides in 42%–93% yields. Good to excellent β-selectivities were obtained for C-glucosides by using tridentate ligand.
