914935-38-9

Basic information

• Product Name: 1-{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}ethanone
• Synonyms: 1-{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}ethanone
• CAS NO: 914935-38-9
• Molecular Weight: 537.722
• Mol File: 914935-38-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}ethanone(914935-38-9)
• EPA Substance Registry System: 1-{5-({[tert-butyl(diphenyl)silyl]oxy}methyl)-4-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2,3-difluorophenyl}ethanone(914935-38-9)

Safety Data

• Hazardous Substances Data: 914935-38-9(Hazardous Substances Data)

Upstream product

• 914935-67-4 (2R,6S)-4-[6-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,3-difluorophenyl]-2,6-dimethylmorpholine 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 141-91-3 cis-2,6-dimethylmorpholine 
• 914935-66-3 [2-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-3,4-difluorophenyl]methanol 
• 914935-65-2 2-((2R,6S)-2,6-dimethylmorpholin-4-yl)-3,4-difluorobenzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 1097626-28-2 1-[4-((2R,6S)-2,6-dimethyl-morpholin-4-yl)-2,3-difluoro-5-hydroxymethyl-phenyl]-ethanone 
• 1223444-75-4 1-(5-((tert-butyldiphenylsilyloxy)methyl)-4-((2R,6S)-2,6-dimethylmorpholino)-3-fluoro-2-(propan-2-ylideneaminooxy)phenyl)ethanone 

Relevant articles and documents

Novel DNA gyrase inhibiting spiropyrimidinetriones with a benzisoxazole scaffold: Sar and in vivo characterization

The compounds described herein with a spirocyclic architecture fused to a benzisoxazole ring represent a new class of antibacterial agents that operate by inhibition of DNA gyrase as corroborated in an enzyme assay and by the inhibition of precursor thymi

CHEMICAL COMPOUNDS

In one aspect, the present invention relates to compounds of Formula (I): to pharmaceutically acceptable sa lts thereof, to methods of using them to treat bacterial infections, and to methods for their preparation.