91296-87-6

Basic information

• Product Name: Sarafloxacin hydrochloride
• Synonyms: Sarafloxacin hydrochloride hydrate ;3-Quinolinec;6-fluoro-1-(4-fluorophenyl)-4-keto-7-piperazin-1-yl-quinoline-3-carboxylic acid hydrochloride;6-fluoro-1-(4-fluorophenyl)-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid hydrochloride;6-fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydrochloride;Sarafloxacin hydrochloride trihydrate;3-Quinolinecarboxylicacid, 6-fluoro-1-(4-fluorophenyl)-1,4-dihydro-4-oxo-7-(1-piperazinyl)-;6-Fluoro-1-(4-fluorophenyl)-4-oxo-7-piperazin-1-yl-1,4-dihydroquinoline-3-carboxylic acid hydr
• CAS NO: 91296-87-6
• Molecular Formula: C₂₀H₁₇F₂N₃O₃*ClH
• Molecular Weight: 421.83
• EINECS: 1806241-263-5
• Product Categories: Pharmacutical raw materials;Active Pharmaceutical Ingredients;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 91296-87-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: >240°C (dec.)
• Boiling Point: 621.4 °C at 760 mmHg
• Flash Point: >110°(230°F)
• Appearance: pale yellow solid
• Vapor Pressure: 2.67E-16mmHg at 25°C
• Storage Temp.: 0-6°C
• Solubility: DMSO (Slightly), Methanol (Very Slightly, Heated)
• Water Solubility: Soluble in water
• CAS DataBase Reference: Sarafloxacin hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Sarafloxacin hydrochloride(91296-87-6)
• EPA Substance Registry System: Sarafloxacin hydrochloride(91296-87-6)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 91296-87-6(Hazardous Substances Data)

Usage

Description

Sarafloxacin hydrochloride is a fluoroquinolone antibacterial agent, which is a synthetic antimicrobial drug belonging to the quinolone class. It exhibits broad-spectrum activity against a variety of bacteria, including both Gram-positive and Gram-negative organisms. Sarafloxacin hydrochloride is characterized by its ability to inhibit bacterial DNA synthesis, leading to the disruption of bacterial cell replication and ultimately resulting in bacterial cell death.

Uses

Used in Veterinary Medicine:
Sarafloxacin hydrochloride is used as a progestin and antiandrogen in veterinary medicine, primarily for the management of reproductive disorders in animals. It helps regulate hormonal balance and supports the treatment of various reproductive issues.
Used in Human Medicine:
As a fluoroquinolone antibacterial agent, Sarafloxacin hydrochloride is used in human medicine for the treatment of bacterial infections. It is particularly effective against a wide range of bacterial pathogens, making it a valuable option for the management of various infectious diseases.
Used in Agriculture:
Sarafloxacin hydrochloride can also be utilized in agriculture as an antibacterial agent to protect crops from bacterial infections. Its broad-spectrum activity allows it to target multiple bacterial species, ensuring the health and productivity of crops.

InChI:InChI=1/C20H17F2N3O3.ClH/c21-12-1-3-13(4-2-12)25-11-15(20(27)28)19(26)14-9-16(22)18(10-17(14)25)24-7-5-23-6-8-24;/h1-4,9-11,23H,5-8H2,(H,27,28);1H

Downstream Products

• 98105-99-8 sarafloxacin 

Relevant articles and documents

Preparation method of quinolone carboxylic acid derivative or phthalazinone carboxylic acid derivative

The invention belongs to the field of pharmaceutical chemicals, relates to a preparation method of a quinolone carboxylic acid derivative or a phthalazinone carboxylic acid derivative, and particularly relates to a preparation method of a 7-substituted-3-quinolone carboxylic acid derivative or a 7-substituted-1,5-phthalazinone carboxylic acid derivative. The preparation method comprises the following steps: (1) in an organic solvent, carrying out coupling reaction on a boron chelate II and organic amine III in the presence of an organosilicon compound to obtain a compound IV; and (2) mixing the compound IV with hydrochloric acid, and then filtering and separating the precipitated compound I. Compared with conventional methods, the preparation method provided by the invention has the advantages that the conditions are milder, the hydrolysis of the substrate quinoline carboxylic acid boric acid ester can be reduced, and meanwhile, the influence of a byproduct HF on the product purity is avoided. The method is high in yield and high in purity; compared with the traditional alkali, the organic silicon is more suitable for industrial preparation of the 7-substituted-3-quinolone carboxylic acid derivative or the 7-substituted-1,5-phthalazinone carboxylic acid derivative.