908291-72-5

Basic information

• Product Name: 3-(1-Naphthalenyloxy)-1-phenyl-1-propanol
• Synonyms: 3-(1-Naphthalenyloxy)-1-phenyl-1-propanol;3-(1-Naphthalenyloxy)-1-phenylpropan-1-ol;α-[2-(1-Naphthalenyloxy)ethyl]benzeneMethanol
• CAS NO: 908291-72-5
• Molecular Formula: C19H18O2
• Molecular Weight: 278.34502
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 908291-72-5.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 3-(1-Naphthalenyloxy)-1-phenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-Naphthalenyloxy)-1-phenyl-1-propanol(908291-72-5)
• EPA Substance Registry System: 3-(1-Naphthalenyloxy)-1-phenyl-1-propanol(908291-72-5)

Safety Data

• Hazardous Substances Data: 908291-72-5(Hazardous Substances Data)

Upstream product

• 20780-53-4 (R)-Styrene oxide 
• 90-15-3 α-naphthol 
• 2768-42-5 (R)-3-phenyl-3-hydroxypropionic acid 
• 100-52-7 benzaldehyde 
• 1375257-37-6 (S)-3-[(R)-3-hydroxy-3-phenylpropanoyl]-4-isopropyl-1-[(R)-1-phenylethyl]imidazolidin-2-one 
• 103548-16-9 (R)-3-phenyl-1,3-dihydroxypropane 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 936-59-4 3-chloropropiophenone 
• 100306-33-0 (1R)-3-chloro-1-phenylpropanol 
• 41198-42-9 3-(naphthalen-1-yloxy)-1-phenylpropan-1-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 100306-34-1 3-chloro-1-phenylpropanol 
• 18776-12-0 3-chloro-1-phenyl-propan-1-ol 

Downstream Products

• 1071929-03-7 Dapoxetine hydrochloride 

Relevant articles and documents

Synthesis method of dapoxetine and dapoxetine hydrochloride

The invention provides a synthesis method of dapoxetine and dapoxetine hydrochloride, and belongs to the technical field of organic synthesis of medicines. The synthesis method of dapoxetine provided by the invention comprises the following steps: 1-naphthol and paraformaldehyde generate 1-naphthol bromomethyl ether under the action of hydrogen bromide, the 1-naphthol bromomethyl ether reacts with magnesium to obtain a 1-naphthol bromomethyl ether Grignard reagent, the 1-naphthol bromomethyl ether Grignard reagent reacts with R-styrene oxide to obtain R-3-(1-naphthyloxy)-1-phenyl propanol, and the R-3-(1-naphthyloxy)-1-phenyl propanol reacts with a bromination reagent to obtain S-1-bromo-1-phenyl-3-(1-naphthyloxy)propane; or the S-1-bromo-1-phenyl-3-(1-naphthyloxy)propane reacts with sulfonyl chloride to obtain S-1-sulfonyloxy-1-phenyl-3-(1-naphthyloxy) propane, or and the S-1-sulfonyloxy-1-phenyl-3-(1-naphthyloxy)propane reacts with sulfonyl chloride to obtain dapoxetine hydrochloride. The synthesis method provided by the invention has the advantages of short synthesis route, high product yield, good product quality, easily available raw materials, low cost and small environmental pollution, and is suitable for industrial production.

Synthetic method of dapoxetine

The invention belongs to the technical field of medicines, in particular to a synthetic method of dapoxetine. The synthetic method comprises the following steps: adding 1-naphthol and 1-phenyl-3-chloropropanol into acetone as a solvent at a temperature of

A hydrochloric acid west reaches anchors the sandbank preparation method (by machine translation)

The invention discloses a method for preparing west reaches anchors the sandbank hydrochloride, including 3 - chlorobenzene propanol, 1 - phenyl - 3 - (1 - naphthoxy) - 1 - propanol, preparation of pure west reaches anchors the sandbank, west reaches anchors the sandbank DTTA salt preparation, preparation of west reaches anchors the sandbank, hydrochloric acid west reaches anchors the sandbank crude preparation and hydrochloric acid west reaches anchors the sandbank preparation of the finished product, the invention, accelerate the speed of production, the saving in material. (by machine translation)