908112-43-6 Usage
Description
4-(6,6-dimethyl-4-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1r,4r)-4-hydroxycyclohexylamino)benzamide, also known as SNX-2112, is a selective heat shock protein 90 (Hsp90) inhibitor. It is a complex organic compound with a unique molecular structure that allows it to target and inhibit the function of Hsp90, a protein that plays a crucial role in the stability and function of various client proteins involved in cell growth and survival.
Uses
Used in Anticancer Applications:
SNX-2112 is used as a potent anticancer agent, particularly against B16 melanoma cells. It exhibits its anticancer activity both in vitro and in vivo by inhibiting cell proliferation and inducing cell cycle arrest and apoptosis. The mechanism behind its anticancer activity is dependent on the degradation of Hsp90 client proteins, which are crucial for the survival and growth of cancer cells.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, SNX-2112 is used as a selective Hsp90 inhibitor for the development of potential therapeutic agents against various types of cancer. Its ability to target and inhibit Hsp90 makes it a promising candidate for the treatment of cancer, as Hsp90 is known to be overexpressed in many cancer cells and plays a critical role in their survival and growth.
Used in Research Applications:
SNX-2112 is also used in research applications to study the role of Hsp90 in various cellular processes and its involvement in the development and progression of cancer. It serves as a valuable tool for researchers to investigate the molecular mechanisms underlying the anticancer activity of Hsp90 inhibitors and to identify potential therapeutic targets for the development of novel cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 908112-43-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,8,1,1 and 2 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 908112-43:
(8*9)+(7*0)+(6*8)+(5*1)+(4*1)+(3*2)+(2*4)+(1*3)=146
146 % 10 = 6
So 908112-43-6 is a valid CAS Registry Number.
908112-43-6Relevant articles and documents
COMBINATION THERAPY FOR TREATING CANCER
-
Page/Page column 63; 74; 75, (2019/02/02)
A method of treating cancer comprising administering an effective amount of each of a chemotherapeutic agent and an Hsp90 inhibitor, either separately or as a covalent conjugate of the two, to provide a combination therapy having an enhanced therapeutic e
