90780-54-4

Basic information

• Product Name: (+/-)8-HDOHE
• Synonyms: (+/-)8-HDOHE;8-HYDROXY DOCOSAHEXAENOIC ACID;(+/-)8-HYDROXY-4Z,6E,10Z,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID;(+/-)10-HDOHE;(+/-)10-HYDROXY-4Z,7Z,11E,13Z,16Z,19Z-DOCOSAHEXAENOIC ACID;10-HYDROXY DOCOSAHEXAENOIC ACID;(±)8-HDHA;ZHBVYDMSPDDAKE-VTIZNUJUSA-N
• CAS NO: 90780-54-4
• Molecular Formula: C22H32 O3
• Molecular Weight: 344.492
• Mol File: 90780-54-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+/-)8-HDOHE(CAS DataBase Reference)
• NIST Chemistry Reference: (+/-)8-HDOHE(90780-54-4)
• EPA Substance Registry System: (+/-)8-HDOHE(90780-54-4)

Safety Data

• Hazardous Substances Data: 90780-54-4(Hazardous Substances Data)

Usage

Description

(+/-)8-HDOHE, also known as (±)8-Hydroxy-5Z,9E,12Z-octadecatrienoic acid, is an isomer of 8-Hydroxydocosahexaenoic acid (8-HDHA) and an autoxidation product of docosahexaenoic acid (DHA). It is produced in vitro and also generated from incubations of DHA in rat liver, brain, and intestinal microsomes. (+/-)8-HDOHE serves as a potential marker of oxidative stress in brain and retina tissues, where DHA is a prevalent polyunsaturated fatty acid.

Uses

Used in Biomarker Research:
(+/-)8-HDOHE is utilized as a biomarker for oxidative stress in brain and retina tissues. Its presence indicates the level of oxidative stress in these areas, which is crucial for understanding the progression of various neurological and ocular disorders.
Used in Pharmaceutical Development:
(+/-)8-HDOHE can be employed in the development of pharmaceuticals targeting oxidative stress-related conditions. By modulating the levels of (+/-)8-HDOHE, researchers can potentially develop treatments to mitigate the effects of oxidative stress in brain and retina tissues.
Used in Nutritional Studies:
(+/-)8-HDOHE can be used in nutritional studies to investigate the effects of diet on oxidative stress levels in the brain and retina. This can help in identifying dietary components that may help reduce oxidative stress and promote overall health.
Used in Diagnostics:
(+/-)8-HDOHE can be incorporated into diagnostic tests to assess the oxidative stress levels in brain and retina tissues. This can aid in early detection of neurological and ocular disorders associated with oxidative stress, enabling timely intervention and treatment.
Used in Antioxidant Research:
(+/-)8-HDOHE can be used in antioxidant research to study the effectiveness of various antioxidants in reducing oxidative stress in brain and retina tissues. This can contribute to the development of novel antioxidant therapies for the prevention and treatment of oxidative stress-related disorders.