906474-56-4Relevant articles and documents
A NEW PROCESS FOR THE PREPARATION OF CANDESARTAN CILEXETIL
-
Page/Page column 13, (2015/07/07)
The present invention discloses the process for the preparation of candesartan cilexetil comprising the steps of hydrogenation of N02group of 1-(((cyclohexyloxy)carbonyl)oxy)ethyl 2-((tert-butoxycarbonyl)((2'-(1-tntyl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)amino)-3-nitrobenzoate by using a catalyst in an organic solvent, subsequent cleavage of the N-Boc group under acidic condition, followed by isolation of solid 1-(((cyclohexyloxy)carbonyl) oxy)ethyl 2-(((2'-(l H-tetrazol-5-yl)-[1,1'-bipheny|]-4-yl)methyl)amino)-3-aminobenzoate in the form of any pharmaceutically acceptable salt and ring closure by using tetraethyl orthocarbonate in an organic solvent to obtain the final product candesartan cilexetil.