90610-69-8 Usage
General Description
3-(4-Sulfamoyl-phenyl)-propionic acid, also known as sulindac, is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. It works by inhibiting the production of prostaglandins, which are responsible for mediating pain, inflammation, and fever. Sulindac is commonly used to relieve symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Additionally, it has been shown to have potential chemopreventive effects, particularly in the prevention of colorectal cancer. However, its use is associated with potential side effects, including gastrointestinal irritation, peptic ulcers, and liver toxicity, and it should be used with caution in patients with a history of these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 90610-69-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,0,6,1 and 0 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 90610-69:
(7*9)+(6*0)+(5*6)+(4*1)+(3*0)+(2*6)+(1*9)=118
118 % 10 = 8
So 90610-69-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO4S/c10-15(13,14)8-4-1-7(2-5-8)3-6-9(11)12/h1-2,4-5H,3,6H2,(H,11,12)(H2,10,13,14)
90610-69-8Relevant articles and documents
Photoinduced Hydrocarboxylation via Thiol-Catalyzed Delivery of Formate across Activated Alkenes
Alektiar, Sara N.,Wickens, Zachary K.
supporting information, p. 13022 - 13028 (2021/09/03)
Herein we disclose a new photochemical process to prepare carboxylic acids from formate salts and alkenes. This redox-neutral hydrocarboxylation proceeds in high yields across diverse functionalized alkene substrates with excellent regioselectivity. This operationally simple procedure can be readily scaled in batch at low photocatalyst loading (0.01% photocatalyst). Furthermore, this new reaction can leverage commercially available formate carbon isotologues to enable the direct synthesis of isotopically labeled carboxylic acids. Mechanistic studies support the working model involving a thiol-catalyzed radical chain process wherein the atoms from formate are delivered across the alkene substrate via CO2?- as a key reactive intermediate.
