9004-74-4

Basic information

• Product Name: Methoxypolyethylene glycols
• Synonyms: 2-ethanediyl),.alpha.-methyl-.omega.-hydroxy-Poly(oxy-1;alpha-methyl-omega-hydroxy-poly(oxy-2-ethanediyl);Ethyleneoxideadductofdiethyleneglycolmonomethylether;methoxypolyethyleneglycol350;methoxypolyethyleneglycol550;monomethoxypolyethyleneglycol;Poly(oxy-1,2-ethanediyl),.alpha.-methyl-.omega.-hydroxy-;Poly(oxyethylenePoly(oxyethylene),.alpha.-methyl-.omega.-hydroxy
• CAS NO: 9004-74-4
• Molecular Formula: C5H12O3
• Molecular Weight: 120.14698
• EINECS: 215-801-2
• Product Categories: Polymers;Cosmetic Ingredients & Chemicals;Non-Ionic Detergents;Detergents;Detergents N to Z;Hydroxy;Materials Science;Monofunctional PEGs;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Optimization Reagents;X-Ray Crystallography;Protein Structural Analysis;Proteomics;Polydispersed PEG;construction;Cosmetic;PEG
• Mol File: 9004-74-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 60-64 °C
• Boiling Point: >200°C/760mmHg
• Flash Point: 268 °C
• Appearance: White to pale yellow/semisolid
• Density: 1.094 g/mL at 25 °C
• Vapor Density: >1 (vs air)
• Vapor Pressure: 0.05 mm Hg ( 20 °C)
• Refractive Index: n20/D 1.459
• Storage Temp.: ?20°C
• Solubility: H2O: 50 mg/mL at 25 °C, clear, colorless
• Water Solubility: Slightly miscible with water.
• Stability: Stable. Incompatible with strong oxidizing agents, strong acids, strong bases.
• CAS DataBase Reference: Methoxypolyethylene glycols(CAS DataBase Reference)
• NIST Chemistry Reference: Methoxypolyethylene glycols(9004-74-4)
• EPA Substance Registry System: Methoxypolyethylene glycols(9004-74-4)

Safety Data

• Safety Statements: 24/25-22
• WGK Germany: 3
• RTECS: PE8271000
• F: 3
• TSCA: Yes
• Hazardous Substances Data: 9004-74-4(Hazardous Substances Data)

Usage

Description

Methoxypolyethylene glycols (MPEGs) are a class of polymers that consist of a polyethylene glycol (PEG) backbone with a methoxy group at one end. The PEG backbone provides hydrophilicity and solubility in aqueous media, while the methoxy group allows for further derivatization or replacement with other reactive functional groups. MPEGs are available in various molecular weights, with MPEG 350 being a common example.

Uses

Used in Pharmaceutical Industry:
Methoxypolyethylene glycols are used as enteric coatings for controlled release and enteric release coatings in the pharmaceutical industry. The hydrophilic PEG spacer enhances solubility and provides a protective barrier that resists degradation in the harsh acidic environment of the stomach, allowing for targeted drug delivery in the intestine.
Used in Drug Delivery Systems:
Methoxypolyethylene glycols are used in the synthesis of thermosensitive micellar cyclotriphosphazenes and amphiphilic poly(organophosphazene) for drug delivery applications. These systems can encapsulate and release drugs in a controlled manner, improving the pharmacokinetics and therapeutic efficacy of various medications.
Used in Bioconjugation and Protein Modification:
Methoxypolyethylene glycols are used in the modification of therapeutic proteins to improve their pharmacokinetics, solubility, and stability. The PEGylation of proteins can reduce immunogenicity, prolong circulation time, and enhance the therapeutic potential of biologics.

InChI:InChI=1/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3