9002-12-4

Basic information

• Product Name: URICASE
• Synonyms: EC 1.7.3.3;EC: 1.7.3.3;IUB: 1.7.3.3;URATE: O2 OXIDOREDUCTASE;URATE OXIDASE;URATE: OXIDOREDUCTASE;URATE: OXYGEN OXIDOREDUCTASE;URATE: OXYGEN OXOREDUCTASE
• CAS NO: 9002-12-4
• Molecular Formula: C18H26N5O14P
• Molecular Weight: 567.397901
• EINECS: 232-655-5
• Product Categories: 1.7.x.x Other nitrogenous donors;1.x.x.x Oxidoreductases;General Metabolic Enzymes;General Metabolic Enzymes I-ZEnzyme Class Index;Metabolomics;enzyme
• Mol File: 9002-12-4.mol
• Article Data: 0

Chemical Properties

• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• Water Solubility: Hardly soluble in water, slightly soluble in buffer alkaline solution.
• Merck: 13,9944
• CAS DataBase Reference: URICASE(CAS DataBase Reference)
• NIST Chemistry Reference: URICASE(9002-12-4)
• EPA Substance Registry System: URICASE(9002-12-4)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• RTECS: YU7100000
• F: 10-21
• TSCA: Yes
• Hazardous Substances Data: 9002-12-4(Hazardous Substances Data)

Usage

Description

URICASE, also known as Urate Oxidase (UO), is a medical enzyme that plays a crucial role in the determination of uric acid in biological fluids. It catalyzes the oxidation of uric acid to 5-hydroxyisourate, making it a valuable tool in clinical analysis. URICASE is typically found in the form of a white powder and has been used in various applications across different industries.

Uses

Used in Clinical Analysis:
URICASE is used as a medical enzyme for the determination of uric acid in biological fluids, such as serum and urine. Its ability to catalyze the oxidation of uric acid makes it an essential tool in clinical analysis for diagnosing and monitoring various conditions related to uric acid levels.
Used in Biosensor Fabrication:
URICASE from Arthrobacter globiformis has been used for coating electrodes in biosensor fabrication, specifically for the detection of uric acid in urine samples. This application allows for accurate and efficient monitoring of uric acid levels in patients.
Used in Analyzing the Effect of Metal Ions:
URICASE has also been employed in analyzing the effect of various metal ions, such as Zn, Cu, Mg, and Mn, on its activity. This research helps in understanding the enzyme's behavior and its potential applications in different environments.
Used in Treating Uric Acid Nephrolithiasis and Diabetes Insipidus:
Mice deficient in URICASE develop uric acid nephropathy and diabetes insipidus, which can be mitigated with recombinant URICASE treatment. This highlights the enzyme's potential therapeutic applications in treating these conditions in humans.

Biochem/physiol Actions

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .