9002-10-2

Basic information

• Product Name: TYROSINASE
• Synonyms: tyrosinase from mushroom;Tyrosinase mushroom;TYROSINASE FROM MUSHROOM, LYOPH., >= 2000 UNITS/MG;PHENOLASE FROM POTATO;TyrosinaseExMushroom;exMushroom;AGARICUSBISPORUSTYROSINASE;Tyrosinase from mushroom,Catechol Oxidase, Monophenol Monooxygenase, Monophenol, dihydroxyphenylalanine:oxygen oxidoreductase, Polyphenol Oxidase
• CAS NO: 9002-10-2
• Molecular Formula: NULL
• EINECS: 232-653-4
• Mol File: 9002-10-2.mol
• Article Data: 0

Chemical Properties

• Melting Point: 89-94 °C
• Appearance: /lyophilized powder
• Storage Temp.: −20°C
• CAS DataBase Reference: TYROSINASE(CAS DataBase Reference)
• NIST Chemistry Reference: TYROSINASE(9002-10-2)
• EPA Substance Registry System: TYROSINASE(9002-10-2)

Safety Data

• Hazard Codes: Xn
• Statements: 42
• Safety Statements: 22-24/25-45
• WGK Germany: 2
• F: 10-21
• Hazardous Substances Data: 9002-10-2(Hazardous Substances Data)

Usage

Description

Tyrosinase, also known as polyphenol oxidase, is a copper-containing oxidase enzyme with a molecular weight ranging from 119.5 kDa to 133 kDa. It has an isoelectric point (pI) of 4.7-5 and an optimum pH of 6-7. Tyrosinase is responsible for browning reactions and has activity for both catechols and cresol. The enzyme has two binding sites for aromatic substrates and a different binding site for oxygen-copper, with the copper likely being Cu(I) and inactivation involving oxidation to Cu(II) ion.

Uses

Used in Pharmaceutical Industry:
Tyrosinase is used as an alternative therapeutic agent for treating hyperpigmentation. It helps in developing treatments that can reduce the appearance of dark spots and uneven skin tone caused by an overproduction of melanin.
Used in Medical Research:
Tyrosinase is used in studies to investigate the oculocutaneous albinism phenotype in various populations, such as the Pakistani population. This helps in understanding the genetic and molecular basis of albinism and developing potential treatments for the condition.
Used in Food Industry:
Although not explicitly mentioned in the provided materials, tyrosinase is also used in the food industry to control enzymatic browning in fruits and vegetables, which helps maintain their appearance and quality during processing and storage.
Used in Cosmetic Industry:
Tyrosinase can be used in the cosmetic industry for developing skin-whitening products and treatments, as it plays a crucial role in melanin production. By targeting tyrosinase activity, it may be possible to create products that help reduce the appearance of hyperpigmentation and uneven skin tone.

Biochem/physiol Actions

Converts tyrosine to L-DOPA or tyramine to dopamine