90-98-2 Usage
Description
4,4'-Dichlorobenzophenone (DBP) is a chemical compound that serves as a versatile intermediate in various organic synthesis processes. It is characterized by the presence of two chlorine atoms attached to the benzophenone molecule, which contributes to its reactivity and utility in different applications.
Uses
Used in Pharmaceutical Industry:
4,4'-Dichlorobenzophenone is used as a pharmaceutical intermediate for the synthesis of various drugs. Its unique chemical structure allows it to be a key component in the development of new pharmaceutical compounds, enhancing their therapeutic properties and effectiveness.
Used in Organic Synthesis:
In the field of organic synthesis, 4,4'-Dichlorobenzophenone is utilized as a valuable intermediate. Its reactivity with other chemical groups makes it suitable for the creation of a wide range of organic compounds, contributing to the advancement of chemical research and development.
Used in Agrochemicals:
4,4'-Dichlorobenzophenone plays a significant role in the agrochemical industry as well. It is used as a raw material and intermediate in the synthesis of various agrochemical products, such as pesticides and herbicides, which are essential for maintaining agricultural productivity and crop protection.
Used in Dye Industry:
The dye industry also benefits from the use of 4,4'-Dichlorobenzophenone. It is employed as an intermediate in the production of various dyes, contributing to the development of new colorants and improving the quality of existing dyes.
Used in Polymer Synthesis:
4,4'-Dichlorobenzophenone can be used to synthesize polyether-polyketones, a type of polymer with potential applications in various industries. Its use in polymer synthesis helps to reduce the overall costs of producing these materials, making them more accessible and affordable.
Used in Environmental Applications:
As a metabolic product resulting from the degradation of DDT, 4,4'-Dichlorobenzophenone has environmental implications. Its study can provide insights into the breakdown of harmful pollutants and contribute to the development of strategies for environmental remediation and pollution control.
Preparation
4,4'-Dichlorobenzophenone is prepared by the acylation of chlorobenzene with 4-chlorobenzoyl chloride. The conversion is typically conducted in the presence of an aluminium chloride catalyst in a petroleum ether solvent.ClC6H5C(O)Cl + C6H5Cl → (ClC6H4)2CO + HCl
Synthesis Reference(s)
The Journal of Organic Chemistry, 54, p. 1201, 1989 DOI: 10.1021/jo00266a039Tetrahedron Letters, 36, p. 8411, 1995 DOI: 10.1016/0040-4039(95)01802-O
Purification Methods
Recrystallise it from EtOH [Wagner et al. J Am Chem Soc 108 7727 1986]. The semicarbazone has m 192-193o (from H2O). [Beilstein 7 H 420, 7 I 228, 7 II 359, 7 III 2076, 7 IV 1376.]
Check Digit Verification of cas no
The CAS Registry Mumber 90-98-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 0 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 90-98:
(4*9)+(3*0)+(2*9)+(1*8)=62
62 % 10 = 2
So 90-98-2 is a valid CAS Registry Number.
90-98-2Relevant articles and documents
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Leebrick,Ramsden
, p. 2259 (1962)
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Organotellurium-catalyzed oxidative deoximation reactions using visible-light as the precise driving energy
Deng, Xin,Qian, Rongrong,Zhou, Hongwei,Yu, Lei
supporting information, p. 1029 - 1032 (2020/10/23)
Irradiated by visible light, the recyclable (PhTe)2-catalyzed oxidative deoximation reaction could occur under mild conditions. In comparison with the thermo reaction, the method employed reduced catalyst loading (1 mol% vs. 2.5 mol%), but afforded elevated product yields with expanded substrate scope. This work demonstrated that for the organotellurium-catalyzed reactions, visible light might be an even more precise driving energy than heating because it could break the Te–Te bond accurately to generate the active free radical catalytic intermediates without damaging the fragile substituents (e.g., heterocycles) of substrates. The use of O2 instead of explosive H2O2 as oxidant affords safer reaction conditions from the large-scale application viewpoint.
Fe-S Catalyst Generated in Situ from Fe(III)- And S3?--Promoted Aerobic Oxidation of Terminal Alkenes
Ai, Jing-Jing,Huang, Cheng-Mi,Li, Jian,Liu, Bei-Bei,Rao, Weidong,Wang, Fei,Wang, Shun-Yi
supporting information, p. 4705 - 4709 (2021/06/28)
An iron-sulfur complex formed by the simple mixture of FeCl3 with S3?- generated in situ from K2S is developed and applied to selective aerobic oxidation of terminal alkenes. The reaction was carried out under an atmosphere of O2 (balloon) and could proceed on a gram scale, expanding the application of S3?- in organic synthesis. This study also encourages us to explore the application of an Fe-S catalyst in organic reactions.