896705-16-1 Usage
Description
BMH21, also known as a planar heterocyclic small molecule DNA intercalator, is a unique compound that has the ability to insert itself between adjacent base pairs in the DNA double helix. This characteristic allows it to interact with DNA and potentially influence biological processes.
Uses
Used in Pharmaceutical Industry:
BMH21 is used as a research compound for studying the interactions between small molecules and DNA. Its DNA intercalating properties make it a valuable tool in understanding the mechanisms of action for potential therapeutic agents.
Used in Cell Culture Applications:
In cell culture, BMH21 is utilized to investigate the effects of DNA intercalation on cellular processes. This can provide insights into the development of new drugs and therapies that target DNA-related pathways or mechanisms.
Used in Cancer Research:
BMH21 is used as a chemotherapeutic agent in cancer research. Its ability to intercalate with DNA can lead to the inhibition of DNA replication and transcription, which can be leveraged to target rapidly dividing cancer cells and potentially halt tumor growth.
Used in Molecular Biology:
BMH21 is used as a molecular probe in molecular biology to study DNA structure, function, and interactions with other molecules. This can contribute to a broader understanding of genetic information and its manipulation for various applications.
Biochem/physiol Actions
BMH-21 is a potent inhibitor of RNA Pol I. BMH-21 binds strongly to GC-rich DNA sequences, ultimately inhibiting RNA Pol I, blocking transcription and disrupting the nucleolar structure. BMH-1 causes dissociation of the RPA194 catalytic subunit from Pol I, and disassembly of Pol I:DNA complexes. The compound BMH-21 inhibits proliferation of a broad range of tumor cell lines.
Check Digit Verification of cas no
The CAS Registry Mumber 896705-16-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,9,6,7,0 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 896705-16:
(8*8)+(7*9)+(6*6)+(5*7)+(4*0)+(3*5)+(2*1)+(1*6)=221
221 % 10 = 1
So 896705-16-1 is a valid CAS Registry Number.
896705-16-1Relevant articles and documents
COMPOUNDS WHICH INHIBIT RNA POLYMERASE, COMPOSITIONS INCLUDING SUCH COMPOUNDS, AND THEIR USE
-
Paragraph 0084, (2015/11/10)
RNA polymerase I (Pol I) is a dedicated polymerase for the transcription of the 47S ribosomal RNA precursor subsequently processed into the mature 5.8S, 18S and 28S ribosomal RNAs and assembled into ribosomes in the nucleolus. Pol I activity is commonly deregulated in human cancers. Based on the discovery of lead molecule BMH-21, a series of pyridoquinazolinecarboxamides were synthesized as inhibitors of Pol I and activators of the destruction of RPA194, the Pol I large catalytic subunit protein. The present invention identifies a set of bioactive compounds, including purified stereoisomers, that potently cause RPA194 degradation that function in a tightly constrained chemical space. Pharmaceutical compositions comprising these compounds and their uses in cancer and other Pol I related diseases is also provided.
