892550-42-4

Basic information

• Product Name: 6,9-dibromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole
• Synonyms: 6,9-dibromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole
• CAS NO: 892550-42-4
• Molecular Weight: 504.583
• Mol File: 892550-42-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 6,9-dibromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6,9-dibromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole(892550-42-4)
• EPA Substance Registry System: 6,9-dibromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazole(892550-42-4)

Safety Data

• Hazardous Substances Data: 892550-42-4(Hazardous Substances Data)

Upstream product

• 387-45-1 2-chloro-6-fluorobenzaldehyde 
• 53348-05-3 3,6-dibromo-phenanthrene-9,10-dione 

Downstream Products

• 892549-32-5 2-[9-chloro-6-(3-hydroxy-3-methylbutyl-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]-3-fluorobenzonitrile 
• 947531-49-9 2-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]-1,1,1,3,3,3-hexafluoropropan-2-ol 
• 947531-89-7 1-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]-2,2,2-trifluoroethane-1,1-diol 

Relevant articles and documents

2-(PHENYL OR HETEROCYCLIC) - 1H-PHENANTHRO [9,10-D] IMIDAZOLES

The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

METHODS FOR TREATING OR PREVENTING NEOPLASIAS

The present invention is directed to a method for treating or preventing a neoplasia in a human patient in need of such treatment comprising administering to the patient a compound that inhibits microsomal prostaglandin E synthase-1 in an amount that is effective for treating or preventing the neoplasia.