89-59-8 Usage
Description
4-Chloro-2-nitrotoluene is an organic compound that is characterized by the presence of a chlorine atom at the 4-position and a nitro group at the 2-position on a toluene molecule. It is a versatile intermediate in the synthesis of various chemical compounds and has potential applications in different industries.
Uses
Used in Pharmaceutical Industry:
4-Chloro-2-nitrotoluene is used as a key intermediate in the synthesis of NMDA-glycine antagonists, which are important for the development of drugs targeting neurological disorders.
Used in Pharmaceutical Industry:
4-Chloro-2-nitrotoluene is also used in the preparation of COX-2 inhibitors, which are nonsteroidal anti-inflammatory drugs used for treating pain and inflammation.
Used in Dye Industry:
4-Chloro-2-nitrotoluene can be used in the synthesis of indigo dye, a blue pigment commonly used in the textile industry for dyeing and printing.
Biochem/physiol Actions
4-Chloro-2-nitrotoluene is the starting reagent for synthesis of tricyclic indole-2-carboxylic acids, a potential NMDA-glycine antagonists.
Check Digit Verification of cas no
The CAS Registry Mumber 89-59-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 9 respectively; the second part has 2 digits, 5 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 89-59:
(4*8)+(3*9)+(2*5)+(1*9)=78
78 % 10 = 8
So 89-59-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO2/c1-5-2-3-6(8)4-7(5)9(10)11/h2-4H,1H3
89-59-8Relevant articles and documents
Conformations, equilibrium thermodynamics and rotational barriers of secondary thiobenzanilides
Kozic, Ján,Novák, Zdeněk,?ímal, Václav,Profant, Václav,Kune?, Ji?í,Vin?ová, Jarmila
, p. 2072 - 2083 (2016/04/09)
The article deals with conformational behaviour of 2-methoxy-2′-hydroxythiobenzanilides. The CS-NH group of these compounds preferentially adopts the Z-conformation. Entropy favours the Z-conformer over the E-conformer, whereas enthalpy slightly favours the E-conformer over the Z-conformer. The rotational barrier about the CS-NH bond was determined to be (81.5±0.4) kJ/mol. No significant rotational barrier was found on the Ar-CS and Ar-NH bonds. All experimental outcomes are compared with the results of quantum-chemical calculations.
Bis(dealkoxycarbonylation) of nitroarylmalonates: A facile entry to alkylated nitroaromatics
Gurjar,Reddy,Murugaiah,Murugaiah
, p. 1659 - 1661 (2007/10/03)
A simple approach to alkylated nitroaromatics from substituted nitroaryl malonic esters by double decarboxylation is detailed.
A veterinary medicament for preventive treatment and therapy of cattle against parasites
-
, (2008/06/13)
A veterinary medicament to control endo- and ectoparasites including larvae of arthropoda, for oral and parenteral therapeutical and prophylactical application, consisting of Ivermectin and N-[5-chloro-4-α-chlorophenyl-α cyano-methyl-2-methyl-phenyl-]-2-hydroxy-3,5-diiodobenzamide.