89-56-5 Usage
Description
5-Methylsalicylic acid is an organic compound derived from salicylic acid, with a methyl group attached at the 5th position. It possesses similar properties to salicylic acid, including its characteristic smell and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
5-Methylsalicylic acid is used as an intermediate in the synthesis of pharmaceutical compounds, due to its structural similarity to salicylic acid and its potential for chemical modification.
Used in Dye Manufacturing:
5-Methylsalicylic acid is used in the manufacturing of dyes, as it can be chemically modified to produce a range of colors and shades.
Used in Analytical Chemistry:
5-Methylsalicylic acid is used in the generation of o-sulfate conjugates in situ and their analysis by ultra-performance liquid chromatography-time-of-flight mass spectrometry, providing a valuable tool for the study of chemical reactions and compound characterization.
Toxicity:
The toxicity of 5-Methylsalicylic acid is similar to that of salicylic acid, which means it should be handled with care and used in appropriate concentrations to avoid adverse effects.
Preparation
5-Methylsalicylic acid can be prepared by hydroxylation of 3-methylbenzoic acid.
Purification Methods
Crystallise the acid from H2O. [Beilstein 10 H 227, 10 II 134, 10 III 516, 10 IV 610.]
Check Digit Verification of cas no
The CAS Registry Mumber 89-56-5 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 8 and 9 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 89-56:
(4*8)+(3*9)+(2*5)+(1*6)=75
75 % 10 = 5
So 89-56-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H8O3/c1-5-2-3-7(9)6(4-5)8(10)11/h2-4,9H,1H3,(H,10,11)/p-1
89-56-5Relevant articles and documents
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Cameron et al.
, p. 233,234 (1950)
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Synthesis of cresotic acids by carboxylation of cresols with sodium ethyl carbonate
Suerbaev, Kh. A.,Chepaikin,Kudaibergenov, N. Zh.,Zhaksylykova, G. Zh.
, p. 646 - 650 (2016/08/16)
Carboxylation of o-cresol, m-cresol, and p-cresol with sodium ethyl carbonate (SEC) proceeds regioselectively with the formation of cresotic acids: 2-hydroxy-3-methylbenzoic acid, 2-hydroxy-4-methylbenzoic acid, and 2-hydroxy-5-methylbenzoic acid, respectively. Optimal conditions for conducting the process have been found to be as follows: the reactants ratio of [cresol]: [sodium ethyl carbonate] = (1.5–2): 1, T = 180–185°C, PCO2 = 10 atm, and t = 6–7 h. Simple and convenient methods for the synthesis of cresotic acids, which can be used for their industrial manufacturing, have been developed.
Carboxylation of Phenols with CO2 at Atmospheric Pressure
Luo, Junfei,Preciado, Sara,Xie, Pan,Larrosa, Igor
supporting information, p. 6798 - 6802 (2016/05/11)
A convenient and efficient method for the ortho-carboxylation of phenols under atmospheric CO2 pressure has been developed. This method provides an alternative to the previously reported Kolbe-Schmitt method, which requires very high pressures of CO2. The addition of a trisubstituted phenol has proved essential for the successful carboxylation of phenols with CO2 at standard atmospheric pressure, allowing the efficient preparation of a broad variety of salicylic acids.