885268-39-3

Basic information

• Product Name: 2-(4-Fluorophenyl)oxazole
• Synonyms: Oxazole, 2-(4-fluorophenyl)-
• CAS NO: 885268-39-3
• Molecular Formula: C₉H₆FNO
• Molecular Weight: 163.15
• Mol File: 885268-39-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Room temperature.
• CAS DataBase Reference: 2-(4-Fluorophenyl)oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-Fluorophenyl)oxazole(885268-39-3)
• EPA Substance Registry System: 2-(4-Fluorophenyl)oxazole(885268-39-3)

Safety Data

• Hazardous Substances Data: 885268-39-3(Hazardous Substances Data)

Usage

General Description

2-(4-Fluorophenyl)oxazole is a chemical compound with the molecular formula C9H6FNO. It is a heterocyclic aromatic compound that contains an oxazole ring, which consists of a five-membered ring with oxygen and nitrogen atoms. 2-(4-Fluorophenyl)oxazole is commonly used in organic synthesis and pharmaceutical research due to its potential biological activities. It is a derivative of oxazole, a naturally occurring heterocyclic compound that is found in various plant and animal tissues. 2-(4-Fluorophenyl)oxazole may have applications in the development of new drugs and pharmaceuticals due to its unique chemical properties and potential biological effects.

Upstream product

• 609345-33-7 oxazol-2-ylzinc(II) chloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 288-42-6 oxazol 
• 352-34-1 4-fluoro-1-iodobenzene 
• 133472-27-2 4-fluorophenylzinc chloride 
• 201017-90-5 2-(methylthio)oxazole 

Downstream Products

• 1429329-80-5 1-(2-(4-fluorophenyl)oxazol-5-yl)-1-(pyridin-4-yl)ethanol 

Relevant articles and documents

Orientation effects on C2(5)-C2?(5?) linked bioxazole isomers synthesized via regioselective and sequential C[sbnd]H arylation

Bis(4-fluorophenyl) substituted oxazole (2,5-Oxz) and C2(5)-C2?(5?) linked bioxazole isomers (C2-C2?_BOxz, C2-C5?_BOxz and C5-C5?_BOxz) were concisely synthesized via palladium-catalyzed regioselective and sequential C[sbnd]H arylation in 1–3 reaction steps along with 20%–83% of total yields from oxazole and 4-bromofluorobenzene. The linking orientation plays a key role in the packing geometry and photophysical properties of C2-C2'_BOxz, C2-C5'_BOxz and C5-C5'_BOxz. These bioxazole isomers in solid state showed significant differences in photoluminescence quantum yields (PLQY) (0.33, 0.25 and 0.04, respectively), delayed fluorescence properties and powder X-ray diffraction (PXRD) patterns, suggesting the divergence in intermolecular interactions. The theoretically calculated gradient isosurfaces and complexation energies indicate the existence of intense π-π interactions between molecular layers, which are in good agreement with the variation trend of optical properties.

PYRIDINE DERIVATIVES

The present application provides novel pyridine compounds and pharmaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. These compounds are useful in inhibiting CYP 17 activity by administering a therapeutically effective amount of one or more of the compounds to a patient. By doing so, these compounds are effective in treating conditions associated with CPY17 activity. A variety of conditions can be treated using these compounds and include diseases which are characterized by abnormal cellular proliferation. In one embodiment, the disease is cancer, such as prostate cancer.