88431-04-3Relevant articles and documents
Formation of o-Allyl- And Allenyl-Modified Amides via Intermolecular Claisen Rearrangement
Niu, Zhi-Jie,Li, Lian-Hua,Li, Xue-Song,Liu, Hong-Chao,Shi, Wei-Yu,Liang, Yong-Min
supporting information, p. 1315 - 1320 (2021/02/20)
We developed a new transition-metal-free intermolecular Claisen rearrangement process to introduce allyl and allenyl groups into the α position of tertiary amides. In this transformation, amides were activated by trifluoromethanesulfonic anhydride to produce the keteniminium ion intermediates that exhibit strong electrophilic activity. This atom-economical process delivers α position-modified amides under mild conditions in moderate to good yields and showcases a broad substrate compatibility.
Asymmetric synthesis of intermediates for retroviral protease inhibitor compounds
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, (2008/06/13)
The disclosure describes an improved process for producing optically active compounds of Formula II or III, which compounds are useful as intermediates for preparing compounds active as inhibitors of retroviral protease enzymes: STR1 wherein R1