882562-58-5Relevant articles and documents
Targeting the Gatekeeper MET146 of C-Jun N-Terminal Kinase 3 Induces a Bivalent Halogen/Chalcogen Bond
Lange, Andreas,Günther, Marcel,Büttner, Felix Michael,Zimmermann, Markus O.,Heidrich, Johannes,Hennig, Susanne,Zahn, Stefan,Schall, Christoph,Sievers-Engler, Adrian,Ansideri, Francesco,Koch, Pierre,Laemmerhofer, Michael,Stehle, Thilo,Laufer, Stefan A.,Boeckler, Frank M.
supporting information, p. 14640 - 14652 (2015/12/09)
We target the gatekeeper MET146 of c-Jun N-terminal kinase 3 (JNK3) to exemplify the applicability of X···S halogen bonds in molecular design using computational, synthetic, structural and biophysical techniques. In a designed series of aminopyrimidine-ba
Synthesis and SAR of aminopyrimidines as novel c-Jun N-terminal kinase (JNK) inhibitors
Alam, Mahbub,Beevers, Rebekah E.,Ceska, Tom,Davenport, Richard J.,Dickson, Karen M.,Fortunato, Mara,Gowers, Lewis,Haughan, Alan F.,James, Lynwen A.,Jones, Mark W.,Kinsella, Natasha,Lowe, Christopher,Meissner, Johannes W.G.,Nicolas, Anne-Lise,Perry, Benjamin G.,Phillips, David J.,Pitt, William R.,Platt, Adam,Ratcliffe, Andrew J.,Sharpe, Andrew,Tait, Laura J.
, p. 3463 - 3467 (2008/02/09)
The development of a series of novel aminopyrimidines as inhibitors of c-Jun N-terminal kinases is described. The synthesis, in vitro inhibitory values for JNK1, JNK2 and CDK2, and the in vitro inhibitory value for a c-Jun cellular assay are discussed.
