882-36-0

Basic information

• Product Name: N-Benzylacetoacetamide
• Synonyms: ACETOACETBENZYLAMIDE;BENZYLACETOACETAMIDE;BENZYL ACETOACETIC AMIDE;N-BENZYLACETOACETAMIDE;N-ACETOACETYLBENZYLAMINE;3-oxo-n-(phenylmethyl)-butanamid;AAPCT;N-Benzyl-3-Oxo-Butanamide
• CAS NO: 882-36-0
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• EINECS: 212-928-5
• Product Categories: Aromatics Compounds;Aromatics
• Mol File: 882-36-0.mol
• Article Data: 42

Chemical Properties

• Melting Point: 103 °C
• Boiling Point: 399.4 °C at 760 mmHg
• Flash Point: 174.4 °C
• Appearance: Light Yellow Powder
• Density: 1.093 g/cm³
• Vapor Pressure: 1.38E-06mmHg at 25°C
• Refractive Index: 1.522
• Solubility: Acetone, Dichloromethane, Ethyl Acetate
• PKA: 7.90±0.50(Predicted)
• CAS DataBase Reference: N-Benzylacetoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzylacetoacetamide(882-36-0)
• EPA Substance Registry System: N-Benzylacetoacetamide(882-36-0)

Safety Data

• Hazardous Substances Data: 882-36-0(Hazardous Substances Data)

Usage

Chemical Properties

Light Yellow Powder

InChI:InChI=1/C11H13NO2/c1-9(13)7-11(14)12-8-10-5-3-2-4-6-10/h2-6H,7-8H2,1H3,(H,12,14)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 41270-27-3 N-benzyl-dithiocarbamic acid ammonium salt 
• 67-56-1 methanol 
• 10128-99-1 3-benzyl-6-methyl-[1,3]oxazine-2,4-dione 
• 71-23-8 propan-1-ol 
• 64-17-5 ethanol 
• 60-23-1 Cysteamine 
• 71-36-3 butan-1-ol 
• 121767-19-9 1-Phenyl-2-aza-3-trimethylsilyloxy-1,3-butadiene 
• 75-36-5 acetyl chloride 
• 105-45-3 acetoacetic acid methyl ester 
• 100-46-9 benzylamine 
• 141-97-9 ethyl acetoacetate 
• 65399-20-4 S-(4-chlorophenyl) 3-oxobutanethioate 

Downstream Products

• 95873-08-8 2,4-diacetyl-N,N'-dibenzyl-glutaramide 
• 31010-20-5 2-Brom-acetessigsaeure- 
• 51903-67-4 Acetoacet-N-benzylamid-2,3-dioxim 
• 3173-56-6 benzyl isothiocyanate 
• 93313-67-8 (2-Hydroxy-5-chlor-phenylazo)-acetoacetbenzylamid 
• 82275-32-9 N-Benzyl-3-methyl-3-(morpholinoamino)acrylamid 
• 106538-05-0 1,3,6-Trimethyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid benzylamide 
• 106538-04-9 3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyrazine-5-carboxylic acid benzylamide 
• 77335-87-6 2-(hydroxyimino)-3-oxo-N-benzylbutanamide 
• 102313-71-3 N,1-dibenzyl-2,4-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide 
• 89232-29-1 N-benzyl-3-hydroxybutanamide 
• 115395-12-5 (S)-N-benzyl-3-hydroxybutanamide 
• 91305-86-1 3-acetyl-4-amino-1-benzyl-1H-pyrrole-2,5-dione 
• 1027948-17-9 (R)-((Z)-2-Benzylcarbamoyl-1-methyl-vinylamino)-phenyl-acetic acid ethyl ester 

Relevant articles and documents

Nickel-promoted oxidative domino Csp3-H/N-H bond double-isocyanide insertion reaction to construct pyrrolin-2-ones

The first nickel-catalyzed oxidative domino Csp3-H/N-H double isocyanide insertion reaction of acetamides with isocyanides has been developed for the synthesis of pyrrolin-2-one derivatives. A wide range of acetamides bearing various functional groups are compatible with this reaction system by utilizing Ni(acac)2as a catalyst. In this transformation, isocyanide could serve as a C1 connector and insert into the inactive Csp3-H bond, representing an effective way to construct heterocycles.

2- Amino -3,4-dihydropyran -3- formamide analogue as well as preparation method and application thereof

The invention relates to a preparation method 2 - of a compound containing, amino - 333384-dihydropyran - 3 3, which comprises the following step :1) of linking diketene with R. 2 NH2 The reaction is stirred in a solvent to complete. ;2) Is added R. 3 NH2 , R1 CHO And a of Compound, and adding elemental iodine to reaction solution to complete curing, and drying the filter cake to obtain compound 2 - containing. amino - 3333,4-dihydropyran - 3 3-carboxamide compound, according to the present invention as well as its use. without isolation of intermediate, in a simple.

Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases

Chiral (α-substituted) β-hydroxy amides are interesting derivatives as they are useful building blocks of many biologically active compounds. Herein, the biocatalytic stereocontrolled synthesis of various acyclic syn-α-alkyl-β-hydroxy amides through a dynamic kinetic resolution is shown. Hence, a series of overexpressed alcohol dehydrogenases (ADHs) in Escherichia coli was used to reduce the corresponding racemic β-keto amides. Among them, ADH-A from Rhodococcus ruber and commercial evo-1.1.200 afforded the best activities and selectivities, giving access to the opposite enantiomers with high diastereomeric excess and excellent enantiomeric excess. Some of these compounds were obtained at semipreparative scale. (Figure presented.).