87980-68-5

Basic information

• Product Name: Ingenol-5,20-acetonide-3-O-angelate
• Synonyms: Ingenol-5,20-acetonide-3-O-angelate;Ingenol 5,20-acetonide 3-angelate
• CAS NO: 87980-68-5
• Molecular Formula: C28H38O6
• Molecular Weight: 470.598
• EINECS: -0
• Mol File: 87980-68-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 582.2±50.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 11.38±0.70(Predicted)
• CAS DataBase Reference: Ingenol-5,20-acetonide-3-O-angelate(CAS DataBase Reference)
• NIST Chemistry Reference: Ingenol-5,20-acetonide-3-O-angelate(87980-68-5)
• EPA Substance Registry System: Ingenol-5,20-acetonide-3-O-angelate(87980-68-5)

Safety Data

• Hazardous Substances Data: 87980-68-5(Hazardous Substances Data)

Usage

Description

Ingenol-5,20-acetonide-3-O-angelate is a chemical compound derived from the Ingenol family, which is a group of diterpene esters found in the plant Euphorbia peplus. It is a derivative of Ingenol (I655795) and an analogue of Ingenol 3-Angelate (I655800), characterized by its unique chemical structure and potential biological activities.

Uses

Used in Pharmaceutical Industry:
Ingenol-5,20-acetonide-3-O-angelate is used as a pharmaceutical agent for its anti-tumor activity. It is particularly effective when applied topically for the treatment of actinic keratosis, a precancerous skin condition caused by prolonged exposure to ultraviolet radiation. Ingenol-5,20-acetonide-3-O-angelate's ability to target and eliminate abnormal skin cells makes it a valuable asset in dermatological treatments.
Ingenol-5,20-acetonide-3-O-angelate is also being investigated for its potential applications in cancer therapy, given its anti-tumor properties. Further research is needed to explore its efficacy and safety in treating various types of cancer and to develop suitable drug delivery systems for optimal therapeutic outcomes.

Upstream product

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Downstream Products

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Relevant articles and documents

Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui

Euphorbia kansui showed potent anti-HIV-1 activity during screening of a library composed of plant extracts from Euphorbiaceae and Thymelaeaceae families. Bioassay-guided isolation led to identification of ingenane esters as the active compounds. Further chemical modification resulted in 3-(2-naphthoyl)ingenol (23), which exhibited the most potent anti-HIV-1 activity. Compound 23 also acted as an HIV-1-latency-reversing agent on activation of HIV-1 replication in a latently infected U1 cell model and a T cell latent HIV-1 model JLat-A2.

Semisynthesis of ingenol 3-angelate (PEP005): Efficient stereoconservative angeloylation of alcohols

A high-yielding method was developed for the preparation of ingenol 3-angelate (PEP005, ingenol mebutate) via the corresponding 5,20-acetonide without concomitant isomerization of the angelate (Z-form) to the corresponding tiglate (E-form). The general sc

INGENOL-3-ACYLATES I

The invention relates to compounds of general formula (I) wherein R is (C1-C7)alkyl, (C2-C7)alkenyl or (C2-C7)alkynyl; wherein R is substituted with R1; and pharmaceutically acceptable salt