878757-08-5 Usage
Description
(R)-(-)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine, commonly referred to as "THANDRA", is a chiral amine compound characterized by its intricate molecular structure. It belongs to the amphetamine class of drugs and is recognized for its psychoactive and stimulating properties. As a potent and selective dopamine and norepinephrine releasing agent, THANDRA increases the levels of these neurotransmitters in the brain, which has led to its exploration as a potential treatment for attention-deficit hyperactivity disorder (ADHD). Additionally, its stimulating effects have raised concerns about its potential for recreational use, leading to strict regulation to prevent abuse and addiction.
Uses
Used in Pharmaceutical Industry:
THANDRA is used as a research compound for the development of novel treatments for attention-deficit hyperactivity disorder (ADHD) due to its ability to selectively release dopamine and norepinephrine in the brain. Its psychoactive and stimulating effects make it a promising candidate for further investigation into its therapeutic potential.
Used in Neuroscience Research:
In the field of neuroscience, THANDRA serves as a valuable tool for studying the effects of dopamine and norepinephrine on brain function and behavior. Its potent and selective action on these neurotransmitters allows researchers to gain insights into the underlying mechanisms of various neurological and psychiatric conditions.
Used in Regulatory and Legal Frameworks:
Due to its potential for abuse and addiction, THANDRA is used as a case study in the development and implementation of regulatory and legal frameworks to control the distribution and use of substances with high potential for misuse. This helps ensure public safety and prevent the negative consequences associated with substance abuse.
Check Digit Verification of cas no
The CAS Registry Mumber 878757-08-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,7,8,7,5 and 7 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 878757-08:
(8*8)+(7*7)+(6*8)+(5*7)+(4*5)+(3*7)+(2*0)+(1*8)=245
245 % 10 = 5
So 878757-08-5 is a valid CAS Registry Number.
878757-08-5Relevant articles and documents
An investigation on key parameters that influence the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine: A key intermediate for duloxetine
Suthrapu, Sashikanth,Sripathi, Somaiah,Veeramalla, Raju,Bojja, Ramachandra Reddy,Karnati, Venugopal Reddy
, p. 854 - 856 (2009)
This document highlights the systematic study of influencing factors such as temperature, base, catalyst, and solvent volume in the synthesis of (S)-(+)-N,N-dimethyl-3-(1-naphthalenyloxy)-3-(2-thienyl)propylamine oxalate 11a, without affecting the chiral
PROCESS FOR THE PREPARATION OF DULOXETINE
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Page/Page column 7, (2008/06/13)
The invention relates to a process for the preparation of duloxetine (1a), comprising the reaction between 1-fluoronaphthalene and 3-N,N-dimethylamino-l-(2-thienyl)-propan-l-ol in the presence of l,3-dimethyl-2-oxo-hexahydropyrimidine (DMPU) as the solvent; a method for the identification of duloxetine enantiomers and for the determination of its optical purity is also disclosed.
