87679-71-8

Basic information

• Product Name: Trandolaprilat
• Synonyms: 1-(2-((1-Carboxy-3-phenylpropyl)amino)-1-oxopropyl)octahydro-1H-indole-2-carboxylicacid;Trandolaprilat Monohydrate;(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid Monohydrate;RU-44404;Trandolaprilate Monohydrate;(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-Carboxy-3-phenylpropyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid;Trandolaprilate;(2S,3aR,7aS)-1-((S)-N-((S)-1-Carboxy-3-phenylpropyl)alanyl)hexahydro-2-indolinecarboxylic acid
• CAS NO: 87679-71-8
• Molecular Formula: C22H30N2O5
• Molecular Weight: 402.48
• Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Isotope Labeled Compounds;Trandolapril
• Mol File: 87679-71-8.mol
• Article Data: 0

Chemical Properties

• Melting Point: 132-134°C
• Boiling Point: 640.5 °C at 760 mmHg
• Flash Point: 341.2 °C
• Appearance: pale yellow solid
• Density: 1.247 g/cm³
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
• PKA: 2.20±0.10(Predicted)
• CAS DataBase Reference: Trandolaprilat(CAS DataBase Reference)
• NIST Chemistry Reference: Trandolaprilat(87679-71-8)
• EPA Substance Registry System: Trandolaprilat(87679-71-8)

Safety Data

• Hazardous Substances Data: 87679-71-8(Hazardous Substances Data)

Usage

Description

Trandolaprilat is a metabolite of Trandolapril, which is an antihypertensive drug. It functions as an angiotensin-converting enzyme (ACE) inhibitor, playing a crucial role in the regulation of blood pressure.

Uses

Used in Pharmaceutical Industry:
Trandolaprilat is used as an active metabolite for the treatment of hypertension. As an ACE inhibitor, it helps in lowering blood pressure by blocking the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This action leads to vasodilation and a reduction in peripheral vascular resistance, ultimately contributing to the management of high blood pressure.
Additionally, Trandolaprilat is used as a labeled metabolite in research and development for studying the pharmacokinetics, pharmacodynamics, and potential drug interactions of Trandolapril. This application aids in understanding the drug's behavior in the body and its therapeutic effects, ensuring the safety and efficacy of the medication.

InChI:InChI=1/C22H30N2O5.H2O/c1-14(23-17(21(26)27)12-11-15-7-3-2-4-8-15)20(25)24-18-10-6-5-9-16(18)13-19(24)22(28)29;/h2-4,7-8,14,16-19,23H,5-6,9-13H2,1H3,(H,26,27)(H,28,29);1H2/t14-,16+,17-,18-,19-;/m0./s1