874485-32-2

Basic information

• Product Name: (25RS)-Ruscogenin
• Synonyms: (25RS)-Ruscogenin
• CAS NO: 874485-32-2
• Molecular Formula: C27H42O4
• Molecular Weight: 430.62
• EINECS: -0
• Mol File: 874485-32-2.mol
• Article Data: 24

Chemical Properties

• Boiling Point: 563.1±50.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: 14.56±0.70(Predicted)
• CAS DataBase Reference: (25RS)-Ruscogenin(CAS DataBase Reference)
• NIST Chemistry Reference: (25RS)-Ruscogenin(874485-32-2)
• EPA Substance Registry System: (25RS)-Ruscogenin(874485-32-2)

Safety Data

• Hazardous Substances Data: 874485-32-2(Hazardous Substances Data)

Usage

Uses

(25RS)-Ruscogenin is a steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities.

Upstream product

• 17676-33-4 spirosta-5(6),25(27)-diene-1β,3β-diol 
• 39491-38-8 alliospiroside A 
• 105798-62-7 alliofuroside A 
• 201858-25-5 (20S,22R,25R)-1α,2α-epoxyspirosta-4,6-dien-3-one 
• 41753-55-3 25(S)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-fucopyranoside 
• 105822-00-2 22-O-methyl ether of alliofuroside A 
• 87425-34-1 25(S)-ruscogenin 1-O-β-D-fucopyranosido-3-O-α-L-rhamnopyranoside 
• 87436-70-2 25(S)-ruscogenin 3-O-L-rhamnopyranoside 
• 38971-41-4 25(S)-ruscogenin 1-O-α-L-rhamnopyranosyl-(1->2)-β-D-fucopyranoside 
• 87436-70-2 ruscogenin 3-O-α-L-rhamnopyranoside 

Downstream Products

• 79037-13-1 1β,3β-dibenzoyloxycholest-5-ene-16β-ol 
• 79037-12-0 C₄₂H₅₆O₇S 
• 79037-04-0 1β,3β,16β-tribenzoyloxycholest-5-ene 
• 79037-07-3 1β,3β,16β,26-tetrabenzoyloxycholest-5-ene 
• 79037-17-5 (20S,22R,25R)-1α,3β-dihydroxyspirost-5-ene 

Relevant articles and documents

Steroidal glycosides from the underground parts of Dracaena thalioides and their cytotoxic activity

Six spirostanol glycosides (1-6) and 12 known compounds (7-18) were isolated from the underground parts of Dracaena thalioides (Agavaceae). Their structures were determined by spectroscopic analysis, including 2D NMR spectroscopic data, and chemical transformations. The isolated compounds were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1, 3-6, and 8-18 showed cytotoxicity against HL-60 cells, of which 10, a bisdesmosidic spirostanol derivative, showed potent cytotoxicity against HL-60 cells with an IC50 value of 0.38 μM and induced apoptosis in HL-60 cells.

New neuritogenic steroidal saponin from Ophiopogon japonicus (Thunb.) Ker-Gawl

A new steroidal saponin was isolated from Ophiopogon japonicus. This saponin possesses a modification by 2-hydroxy-3-methylvalerylation of the hydroxyl group at C-4' of the sugar, linked to C-1 of the aglycone. It exhibited significant neuritogenic activity for PC12 cells. The structure-activity relationship revealed the aglycone, rather than the sugar moieties and acylation, to be important for the neuritogenic activity.

Highly efficient and regio-selective glucosylation of 25(S) ruscogenin by Gliocladium deliquescens NRRL1086

A new steroidal glycoside, 25(S) ruscogenin 1-O-β-D-glucopyranoside (2) was obtained through the microbial transformation of 25(S) ruscogenin (1) by G. deliquescens NRRL1086 in 54% isolated yield. The structure of the product was elucidated by IR, MS and NMR spectra. This is the first report on the preparation of steroidal saponins by microbial transformation.