874384-22-2

Basic information

• Product Name: (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid
• Synonyms: (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid
• CAS NO: 874384-22-2
• Molecular Weight: 546.664
• Mol File: 874384-22-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid(874384-22-2)
• EPA Substance Registry System: (R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid(874384-22-2)

Safety Data

• Hazardous Substances Data: 874384-22-2(Hazardous Substances Data)

Upstream product

• 874384-21-1 (R)-1-((S)-2-{2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-dimethyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-propionylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid 
• 71989-31-6 (R)-Pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester 
• 850209-99-3 2-dibenzylamino-5-oxo-pentanoic acid benzyl ester 
• 167905-35-3 (S)-2-dibenzylaminopentanedioic acid dibenzyl ester 
• 35661-40-6 N-Fmoc L-Phe 
• 16338-48-0 L-allylglycine 
• 874384-12-0 (2S,9R)-2-(tert-butoxycarbonylamino)-9-(tert-butyldimethylsilyloxy)-8-oxo-6-decanoic acid 
• 874384-02-8 (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester 
• 874384-03-9 (E)-(S)-2-Dibenzylamino-6-methoxy-hex-5-enoic acid benzyl ester 
• 874384-01-7 benzyl (S)-2-(dibenzylamino)pent-4-enoate 
• 850209-98-2 (S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester 

Downstream Products

• 157618-75-2 (-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone 

Relevant articles and documents

Synthesis of 2-amino-8-oxodecanoic acids (Aodas) present in natural hystone deacetylase inhibitors

Differently substituted 2-amino-8-oxodecanoic acids (Aodas), present in naturally occurring inhibitors of hystone deacetylase (HDAC), have been prepared using a convergent approach. The configuration in position 2 was derived from enantiomerically pure allylglycine or glutamic acid, whereas the stereochemistry of the substituent in position 9 derived from lactic acid or glyceraldehyde derivatives. Starting from allylglycine, (S)-Aodas, protected at the nitrogen as Boc or Fmoc, were obtained in four steps in about 30% overall yield. These products have been used to prepare a simplified analogue of a natural cyclic tetrapeptide HDAC inhibitor by SPPS.