872674-88-9

Basic information

• Product Name: Benzoic acid, 4-[(2-bromoethyl)sulfonyl]-, methyl ester
• CAS NO: 872674-88-9
• Molecular Formula: C10H11BrO4S
• Molecular Weight: 307.165
• Mol File: 872674-88-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[(2-bromoethyl)sulfonyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[(2-bromoethyl)sulfonyl]-, methyl ester(872674-88-9)
• EPA Substance Registry System: Benzoic acid, 4-[(2-bromoethyl)sulfonyl]-, methyl ester(872674-88-9)

Safety Data

• Hazardous Substances Data: 872674-88-9(Hazardous Substances Data)

Upstream product

• 6302-65-4 methyl 4-mercaptobenzoate 
• 14184-32-8 4-(2-bromoethylsulfanyl)benzoic acid methyl ester 

Downstream Products

• 872675-00-8 methyl 4-[[2-[4,5-dichloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872674-99-2 methyl 4-[[2-[5,6-dichloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872674-97-0 methyl 4-[[2-[7-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872674-95-8 methyl 4-[[2-[4-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872674-94-7 methyl 4-[[2-[6-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872675-01-9 methyl 4-[[2-[1-(diphenylmethyl)-5-fluoro-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 479422-09-8 methyl 4-[[2-[1-(diphenylmethyl)-5-methoxy-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 479422-06-5 methyl 4-[[2-[1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethyl]sulfonyl]benzoate 
• 872674-92-5 methyl 4-[[2-(5,6-dichloro-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 
• 872674-93-6 methyl 4-[[2-(4,5-dichloro-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 
• 872674-90-3 methyl 4-[[2-(4-chloro-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 
• 872674-89-0 methyl 4-[[2-(6-chloro-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 
• 479422-08-7 methyl 4-[[2-(5-methoxy-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 
• 479421-98-2 methyl 4-[[2-(5-fluoro-2-methyl-1H-indol-3-yl)ethyl]sulfonyl]benzoate 

Relevant articles and documents

Inhibition of cytosolic phospholipase A2α: Hit to lead optimization

Compound 1 was previously reported to be a potent inhibitor of cPLA 2α in both artificial monomeric substrate and cell-based assays. However, 1 was inactive in whole blood assays previously used to characterize cyclooxygenase and lipoxygenase inhibitors. The IC50 of 1 increased dramatically with cell number or lipid/detergent concentration. In an attempt to insert an electrophilic ketone between the indole and benzole acid moieties, we discovered that increasing the distance between the two moieties gave a compound with activity in the GLU (7-hydroxycoumarinyl-γ- linolenate) micelle assay, which contains lipid and detergent. Extensive structure-activity relationship work around this lead identified a potent pharmacophore for cPLA2α inhibition. The IC50s between the GLU micelle and rat whole blood assays correlated highly. No correlation was found for other parameters, including lipophilicity or acidity of the required acid functionality. Compounds 25, 39, and 94 emerged as potent, selective inhibitors of cPLA2α and represent well-validated starting points for further optimization.