871700-22-0

Basic information

• Product Name: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione
• Synonyms: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione;3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-methylamino-1H-pyrimidine-2,4-dione
• CAS NO: 871700-22-0
• Molecular Formula: C₁₄H₁₃FIN₃O₂
• Molecular Weight: 401.1747932
• Mol File: 871700-22-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 459.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.85±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 3.83±0.20(Predicted)
• CAS DataBase Reference: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(871700-22-0)
• EPA Substance Registry System: 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(MethylaMino)pyriMidine-2,4(1H,3H)-dione(871700-22-0)

Safety Data

• Hazardous Substances Data: 871700-22-0(Hazardous Substances Data)

Usage

Description

3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is a chemical compound with a complex structure that features a cyclopropyl group, a fluoro-iodophenyl moiety, and a methylamino substituent. 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is characterized by its potential reactivity and functional groups that can be utilized in various chemical reactions and applications.

Uses

Used in Pharmaceutical Industry:
3-Cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione is used as a reagent for the preparation of 5-amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-d]pyrimidine derivatives and related compounds. These derivatives are of significant interest due to their potential therapeutic applications in the treatment of cancer and rheumatic diseases.
In the development of pharmaceuticals, this compound serves as a key intermediate in the synthesis of various drug candidates. Its unique structural features allow for the creation of molecules that can target specific biological pathways and receptors, offering new avenues for the treatment of challenging medical conditions such as cancer and rheumatic diseases.
The use of 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-6-(methylamino)pyrimidine-2,4(1H,3H)-dione in the pharmaceutical industry highlights the importance of chemical diversity and innovation in drug discovery. By leveraging the properties of this compound, researchers can design and synthesize new molecules with improved efficacy, selectivity, and safety profiles, ultimately contributing to the advancement of medicine and healthcare.

Upstream product

• 871700-30-0 N'-[1-cyclopropyl-3-(2-fluoro-4-iodo-phenyl)-2,6-dioxo-1,2,3,6-tetrahydro-pyrimidin-4-yl]-N,N-dimethyl-formamidine 
• 871700-20-8 6-chloro-3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione 
• 871700-21-9 6-chloro-1-cyclopropyl-3-(2-fluoro-4-iodophenyl)-1H-pyrimidine-2,4-dione 
• 74-89-5 methylamine 

Downstream Products

• 871700-24-2 3-cyclopropyl-1-(2-fluoro-4-iodophenyl)-5-hydroxy-6,8-dimethyl-1H,8H-pyrido[2,3- d]pyrimidine-2,4,7-trione 

Relevant articles and documents

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The invention discloses a method for synthesizing a key intermediate of trametinib, malonic acid monomethyl amide monoethyl ester and isosuccinic acid have a ring-closure reaction to obtain a crude product of a pyridine triketone compound; the obtained cr