86933-74-6 Usage
Description
Neurokinin A, also known as substance K, is an 11 amino acid peptide and a member of the tachykinin family, which includes neurokinin A, neurokinin B, neuropeptide K, neuropeptide Y, and hemokinin-1. It is an endogenous tachykinin agonist with a preference for the NK-2R receptor. The gene encoding neurokinin A is localized on human chromosome 7q21.3.
Uses
Used in Pharmaceutical Industry:
Neurokinin A is used as a therapeutic agent for various conditions, including pain, inflammation, and gastrointestinal disorders. It modulates the activity of the NK-2R receptor, which plays a crucial role in the transmission of pain signals and the regulation of smooth muscle contractions.
Used in Research Applications:
Neurokinin A is used as a research tool to study the physiological functions and mechanisms of action of the tachykinin family of peptides and their receptors. It helps researchers understand the role of neurokinin A in various physiological processes, such as neurotransmission, neuromodulation, and neuroinflammation.
Used in Drug Development:
Neurokinin A is used in the development of new drugs targeting the NK-2R receptor for the treatment of various disorders, such as irritable bowel syndrome, chronic cough, and migraine. By modulating the activity of neurokinin A and its receptor, these drugs aim to provide effective relief from symptoms and improve the quality of life for patients.
Biochem/physiol Actions
Neurokinin A improves the multiplication and paracrine ability of stem cells acquired from adipose in vitro. It participates in the movement of several organ tracts, triggers glandular secretion and controls autonomic reflexes. Neurokinin A plays an important role in neuroimmune and systemic autoimmune/inflammatory conditions like multiple sclerosis (MS), rheumatoid arthritis, inflammatory bowel disease and also in infections and cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 86933-74-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,6,9,3 and 3 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 86933-74:
(7*8)+(6*6)+(5*9)+(4*3)+(3*3)+(2*7)+(1*4)=176
176 % 10 = 6
So 86933-74-6 is a valid CAS Registry Number.
InChI:InChI=1/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)
86933-74-6Relevant articles and documents
Enzymatic fragment condensation of side chain-protected peptides using subtilisin A in anhydrous organic solvents: A general strategy for industrial peptide synthesis
Nuijens, Timo,Schepers, Annette H. M.,Cusan, Claudia,Kruijtzer, John A. W.,Rijkers, Dirk T. S.,Liskamp, Rob M. J.,Quaedflieg, Peter J. L. M.
, p. 287 - 293 (2013/05/21)
Herein, the enzymatic condensation of side chain-protected peptide fragments using subtilisin A in anhydrous organic solvents is described. A screening with dipeptide Cbz-Val-Xxx carboxamidomethyl esters with H-Xxx-Val-NH2 nucleophiles was performed, wherein Xxx stands for every (side chain-protected) amino acid residue. Finally, it was demonstrated that it is feasible to enzymatically condense larger peptide fragments (up to the 10-mer level) bearing multiple side chain-protecting groups with very high conversion.
NEUROKININ &α AND &β, SYNTHESIS AND PHARMACOLOGICAL PROPERTIES
Munekata, Eisuke,Okada, Masahiro,Kimura, Sadao,Sugita, Yoshiki,Kanazawa, Ichiro,et al.
, p. 1013 - 1016 (2007/10/02)
Two novel neuropeptides, neurokinin α and β, isolated from porcine spinal cord were chemically synthesized by solution method.The amino acid sequences proposed were confirmed to be correct and pharmacological properties of neurokinin peptides were studied
