86873-60-1

Basic information

• Product Name: 5-Chloropyridine-2-carboxylic acid
• Synonyms: 5-CHLORO-2-PYRIDINECARBOXYLIC ACID;5-CHLORO-2-PICOLINIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID;5-CHLOROPICOLINIC ACID;5-Chloropyridine-2-carboxylicacid98%;5-CHLORO-2-PYDRIDINECARBOXYLIC ACID;5-CHLOROPYRIDINE-2-CARBOXYLIC ACID 97%;5-CHLORO-2-PICOLINIC ACID (5-CHLORO-2-PYRIDINECARBOXYLIC ACID)
• CAS NO: 86873-60-1
• Molecular Formula: C₆H₄ClNO₂
• Molecular Weight: 157.55
• Product Categories: pharmacetical;Pyridines
• Mol File: 86873-60-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 166-171℃
• Boiling Point: 310.3 °C at 760 mmHg
• Flash Point: 141.5 °C
• Appearance: /
• Density: 1.47 g/cm³
• Vapor Pressure: 0.00026mmHg at 25°C
• Refractive Index: 1.59
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 3.41±0.10(Predicted)
• CAS DataBase Reference: 5-Chloropyridine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloropyridine-2-carboxylic acid(86873-60-1)
• EPA Substance Registry System: 5-Chloropyridine-2-carboxylic acid(86873-60-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-40-22
• Safety Statements: 22-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 86873-60-1(Hazardous Substances Data)

Usage

Description

5-Chloropyridine-2-carboxylic acid is an organic compound with the chemical formula C6H4ClNO2. It is a derivative of pyridine-2-carboxylic acid, featuring a chlorine atom at the 5-position and a carboxylic acid group at the 2-position. 5-Chloropyridine-2-carboxylic acid is known for its potential applications in various fields, particularly in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
5-Chloropyridine-2-carboxylic acid is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of drugs targeting specific enzymes or receptors.
Used in Chemical Industry:
5-Chloropyridine-2-carboxylic acid is used as a building block in the synthesis of various organic compounds, including agrochemicals, dyes, and other specialty chemicals. Its reactivity and functional groups make it a versatile starting material for the creation of new molecules with specific properties.
Used in Research and Development:
5-Chloropyridine-2-carboxylic acid is used as a research compound in academic and industrial laboratories. It serves as a valuable tool for studying the structure-activity relationships of various biologically active molecules and for exploring new synthetic routes to novel compounds.
Used in Inhibitor Development:
5-Chloropyridine-2-carboxylic acid is used as an inhibitor of dopamine β-hydroxylase, an enzyme involved in the biosynthesis of norepinephrine from dopamine. Its inhibitory activity has potential applications in the treatment of hypertension, as it can help regulate blood pressure by modulating the levels of these neurotransmitters.

InChI:InChI=1/C6H4ClNO2/c7-4-1-2-5(6(9)10)8-3-4/h1-3H,(H,9,10)

Upstream product

• 89809-64-3 2-cyano-5-chloropyridine 
• 40473-01-6 2-Bromo-5-chloro-pyridine 
• 124-38-9 carbon dioxide 
• 1072-98-6 5-chloro-2-pyridylamine 
• 16110-09-1 2,5 dichloropyridine 
• 151-21-3 sodium dodecyl-sulfate 
• 109-89-7 diethylamine 
• 1066-54-2 trimethylsilylacetylene 
• 223445-06-5 5-Chloro-2-vinyl-pyridine 
• 132308-15-7 4-(5-chloro-2-pyridyl)-2-methyl-3-butyn-2-ol 
• 858844-85-6 1,3-bis(6-methylpyridin-3-yl)urea 
• 70788-54-4 2,3,4-trichloro-6-(trichloromethyl)pyridine 
• 1199-48-0 4,5-dichloro-2-(trichloromethyl)pyridine 
• 247077-42-5 (6-methyl-[3]pyridyl)-carbamic acid ethyl ester 

Downstream Products

• 1057855-29-4 N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide 
• 1286182-11-3 N-[2-({[(5-chloropyridin-2-yl)carbonyl]amino}methyl)phenyl]-5-methyl-4,5,6,7-tetrahydro[1,3]thiazolo[5,4-c]pyridine-2-carboxamide hydrochloride 
• 1396787-56-6 5-chloro-pyridine-2-carboxylic acid [3-((S)-3-amino-5-methyl-2,5,6,7-tetrahydro-[1,4]thiazepin-5-yl)-4-fluoro-phenyl]-amide 
• 1271948-79-8 5-chloro-pyridine-2-carboxylic acid [3-((S)-2-amino-4-ethyl-5,6-dihydro-4H-[1,3]thiazin-4-yl)-4-fluoro-phenyl]-amide formate 
• 1266786-56-4 5-Chloro-pyridine-2-carboxylic acid [3-((RS)-3-cyclopropyl-5-thioxo-morpholin-3-yl)-4-fluoro-phenyl]-amide 
• 1262859-16-4 (5-{5-[(5-chloropyridine-2-carbonyl)amino]-2-fluorophenyl}-5-trifluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)carbamic acid tert-butyl ester 
• 1262860-00-3 ((R)-5-{5-[(5-chloro-pyridine-2-carbonyl)-amino]-2-fluoro-phenyl}-5-fluoromethyl-5,6-dihydro-2H-[1,4]oxazin-3-yl)-carbamic acid tert-butyl ester 
• 1262038-54-9 tert-butyl (8aS)-8a-(3-(5-chloropicolinamido)phenyl)-4,4a,5,7,8,8a-hexahydropyrano[4,3-d][1,3]thiazin-2-ylcarbamate 
• 1086110-81-7 5-chloro-N-methylpyridine-2-carboxamide 
• 342601-76-7 5-chloro-N-methoxy-N-methylpicolinamide 
• 935997-93-6 C₂₅H₃₁ClN₄O₄S 
• 748183-90-6 5-Chloropyridine-2-carboxylic acid [4-(3-dimethylaminopyrrolidin-1-yl)phenyl]amide 
• 128072-93-5 ethyl 5-chloropyridine-2-carboxylate 
• 132308-19-1 methyl 5-chloropyridine-2-carboxylate 

Relevant articles and documents

Betrixaban structural analogue as well as preparation method and application thereof

The invention provides a novel compound for preparation of drugs for treating venous thrombosis diseases, and particularly relates to a betrixaban structural analogue with a formula (I) shown in the following description or a pharmaceutically acceptable salt thereof, as well as a preparation method and application of the betrixaban structural analogue.

HYDRAZONE COMPOUNDS AND THEIR USE

The present invention relates to hydrazone compounds of Formula I: (I) and pharmaceutically acceptable salts and stereoisomers thereof, wherein R1, R2, R3, R4, L1, and L2 are defined as set forth in the specification. The invention is also directed to the use of compounds of Formula I as inhibitors of TRPM5 protein.

Amide derivative

A compound of the formula: wherein Ar is optionally substituted phenyl, etc.; n is 0, 1 or 2; R1is hydogen atom, optionally substituted alkyl, etc.; R2and R3are independently optionally substituted alkyl, etc.; R4and R5are independently hydrogen atom or optionally substituted alkyl; R6is hydrogen atom, hydroxy or alkyl; or a pharmaceutically acceptable salt thereof is useful as a medicament for treating retinal degenerative disorders and the like.